Browsing Technical documents and research evidence on COVID-19 by Title
Now showing items 1069-1088 of 1749
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Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis
(2020-09-22)Background: There is disagreement about the level of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We conducted a living systematic review and meta-analysis to address three questions: ... -
Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil
(2016-06)IMPORTANCE: The Zika virus (ZIKV) has rapidly reached epidemic proportions, especially in northeastern Brazil, and has rapidly spread to other parts of the Americas. A recent increase in the prevalence of microcephaly in ... -
Of Chloroquine and COVID-19
Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific ... -
Off-Label Real World Experience Using Tocilizumab for Patients Hospitalized with COVID-19 Disease in a Regional Community Health System: A Case-Control Study
(2020-05-19)Objective: To determine if Tocilizumab treatment in patients hospitalized with laboratory confirmed SARS-CoV-2 infection and subsequent COVID-19 disease provides short-term survival benefit. Design: Case-control, observational ... -
Off-label use of medicines for COVID-19. Scientific brief, 31 March 2020
(2020-03-31)No pharmaceutical products have yet been shown to be safe and effective for the treatment of COVID-19. However, a number of medicines have been suggested as potential investigational therapies, many of which are now being ... -
Off‐label Use of Tocilizumab in Patients with SARS‐CoV‐2 Infection
(2020-04-16)The spread of the novel‐Coronavirus infection worldwide represents a challenge for physicians. Particularly, no approved therapy has demonstrated to have an impact in treating patients who develop severe respiratory ... -
Olfactory Dysfunction in Coronavirus Disease 2019 Patients: Observational Cohort Study and Systematic Review
(2020-06)Background - Olfactory dysfunction (OD) has been reported in coronavirus disease 2019 (COVID-19). However, there are knowledge gaps about the severity, prevalence, etiology, and duration of OD in COVID-19 patients. Methods ... -
On the impact of early non-pharmaceutical interventions as containment strategies against the COVID-19 pandemic
(2020-05-09)Background The novel coronavirus SARS-CoV-2 (COVID-19) emerged in December 2019 in Wuhan, China and has spread since then to around 210 countries and territories by April 2020. Consequently, countries have adopted physical ... -
One-step RT-PCR for detection of Zika virus
(2014)Zika virus (ZIKV) is an emerging mosquito-borne flavivirus circulating in Asia and Africa. Human infection induces an influenza-like syndrome that is associated with retro-orbital pain, oedema, lymphadenopathy, or diarrhea. ... -
Ongoing Living Update of Potential COVID-19 Therapeutics Options: Summary of Evidence. Rapid Review
(2020-12-18)Summary of rapid systematic reviews, from the 8th edition of the document and above. -
Ongoing Living Update of Potential COVID-19 Therapeutics: Summary of Rapid Systematic Reviews, 16 June 2020
(2020-06-16)Take home message thus far: • We examined 24 therapeutic options thus far; currently, there is no evidence of any important benefit from any therapeutic option (though remdesivir is revealing promise as one option based ... -
Ongoing Living Update of Potential COVID-19 Therapeutics: Summary of Rapid Systematic Reviews. Rapid Review, 13 July 2020
(2020-07-13)This document includes the results of a rapid systematic review of currently available literature. The information included in this review reflects the evidence as of the date posted in the document. Yet, recognizing that ... -
Ongoing Living Update of Potential COVID-19 Therapeutics: summary of rapid systematic reviews. Rapid Review, 22 April 2020
(2020-04-22)This document includes the results of a rapid systematic review of current available literature. The information included in this review reflects the evidence as of the date posted in the document. Yet, recognizing that ... -
Ongoing Living Update of Potential COVID-19 Therapeutics: Summary of Rapid Systematic Reviews. Rapid Review, 8 September 2020
(2020-09-11)More than 200 therapeutic options or their combinations are being investigated in more than 1,700 clinical trials. In this review, we have examined 40 therapeutic options. The Pan American Health Organization (PAHO) is ... -
Ongoing Zika Virus Transmission - Puerto Rico, November 1, 2015-April 14, 2016
(2016-06)Zika virus is a flavivirus transmitted primarily by Aedes species mosquitoes, and symptoms of infection can include rash, fever, arthralgia, and conjunctivitis (1).* Zika virus infection during pregnancy is a cause of ... -
Operational considerations for managing COVID-19 cases and outbreaks on board ships, Interim guidance 24 February 2020
(2020-02-24)Overview: This document has been prepared based on the evidence currently available about Coronavirus disease 2019 (COVID-19) transmission (human-to-human transmission via respiratory droplets or direct contact from an ... -
Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection
(2016-06)PURPOSE: In 2015, a twenty-fold increase in the prevalence of microcephaly in Brazil was reported, and the Ministry of Health associated this abnormal prevalence with the maternal-fetal Zika virus (ZIKV) transmission. ... -
Optimal strategies for quarantine stopping in France. General expected patterns of strategies focusing on contact between age groups
(2020-04-24)Due to the COVID-19 pandemic, many countries have implemented a complete lock-down of their population that may not be sustainable for long. To identify the best strategy to replace this full lock-down, sophisticated models ... -
Optimizing Medication Management During the COVID-19 Pandemic: It Takes a Village
(2020-06-29)Coronavirus disease 2019 (COVID-19) is an unprecedented pandemic that has particularly affected nursing homes and long-term care facilities. To support frontline health care professionals caring for older adults, the current ...