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Zika Virus, a New Threat for Europe?
(2016)Since its emergence in 2007 in Micronesia and Polynesia, the arthropod-borne flavivirus Zika virus (ZIKV) has spread in the Americas and the Caribbean, following first detection in Brazil in May 2015. The risk of ZIKV ... -
Time Lags between Exanthematous Illness Attributed to Zika Virus, Guillain-Barré Syndrome, and Microcephaly, Salvador, Brazil
(2016)Zika virus infection emerged as a public health emergency after increasing evidence for its association with neurologic disorders and congenital malformations. In Salvador, Brazil, outbreaks of acute exanthematous illness ... -
Febrile or Exanthematous Illness Associated with Zika, Dengue, and Chikungunya Viruses, Panama
(2016)The earliest clinical cases of Zika virus infection were reported from continental South America in 2015 (1), after which the virus spread rapidly through the Americas (2). Here we describe an investigation of febrile or ... -
Hearing Loss in Infants with Microcephaly and Evidence of Congenital Zika Virus Infection - Brazil, November 2015-May 2016
(2016)Congenital infection with Zika virus causes microcephaly and other brain abnormalities (1). Hearing loss associated with other congenital viral infections is well described; however, little is known about hearing loss in ... -
Specificity of dengue NS1 antigen in differential diagnosis of dengue and zika virus infection
(2016)Circulation of new arboviruses of the genus Flavivirus poses a major problem for differential diagnosis. Zika virus, a mosquitoborne virus of the family Flaviviridae, is closely related to other arboviruses circulating in ... -
Zika virus and blood transfusion: the experience of French Polynesia
(2017)Background: Between October 2013 and March 2014, French Polynesia experienced the largest Zika virus (ZIKV) outbreak ever described before the emergence of ZIKV in the Americas in 2015. As arbovirus transfusion-transmitted ... -
Associated ultrasonographic findings in fetuses with microcephaly because of suspected Zika virus (ZIKV) infection during pregnancy
(2016)OBJECTIVE: To describe fetal ultrasonographic findings and outcomes in a series of cases of fetal microcephaly associated with Zika virus infection. METHODS: Retrospective case series of microcephaly with definite ... -
A detailed comparative analysis of codon usage bias in Zika virus
(2016)Zika virus (ZIKV) is a member of the family Flaviviridae and its genome consists of a single-stranded positive sense RNA molecule with 10,794 nucleotides. Clinical manifestations of disease caused by ZIKV infection range ... -
Study of INTERCEPT Blood System for Red Blood Cells in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections (RedeS) RedeS
(2017)Stage A: To evaluate the safety and efficacy of the INTERCEPT Blood System for Red Blood Cells Pathogen Reduction Treatment (PRT) in comparison to conventional RBCs in adult patients who require RBC transfusion support. Stage ... -
Safety, Tolerability, and Immunogenicity of mRNA-1325 in Healthy Adult Subjects
(2017)The clinical study will assess the safety, tolerability, and immunogenicity of mRNA-1325 in healthy adult subjects. Study Type: Interventional Study Design: Allocation: Randomized Intervention Model: Parallel ... -
Birth Defects Among Fetuses and Infants of US Women With Evidence of Possible Zika Virus Infection During Pregnancy
(2017)IMPORTANCE: Understanding the risk of birth defects associated with Zika virus infection during pregnancy may help guide communication, prevention, and planning efforts. In the absence of Zika virus, microcephaly occurs ... -
Applying Wolbachia to Eliminate Dengue AWED
(2017)This cluster randomised trial will evaluate the efficacy of Wolbachia-infected Aedes aegytpi mosquitoes in reducing dengue cases in Yogyakarta City, Indonesia. Primary objective: To assess the efficacy of community-based ... -
Managing intensive care admissions when there are not enough beds during the COVID-19 pandemic: a systematic review
(2020-12-17)The surge in cases of severe COVID-19 has resulted in clinicians triaging intensive care unit (ICU) admissions in places where demand has exceeded capacity. In order to assist difficult triage decisions, clinicians require ... -
Adverse effects of non-steroidal anti-inflammatory drugs in patients with viral respiratory infections: rapid systematic review
(2020-11-19)Objectives: To assess the effects of non-steroidal anti-inflammatory drugs (NSAIDs) in patients with viral respiratory infections on acute severe adverse outcomes, healthcare utilisation, quality of life and long-term ... -
Effect of the COVID-19 pandemic on mortality of patients with STEMI: a systematic review and meta-analysis
(2020-12-17)[Abstract]. Aims Since the beginning of the SARS-CoV-2 outbreak, hospitals reported declining numbers of patients admitted with ST-segment elevation myocardial infarction (STEMI), indicating that the pandemic might keep ... -
A systematic review of the literature on the role of tracheostomy in COVID-19 patients
(2020-12-01)The Coronavirus Disease 2019 (COVID-19) is a viral infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which emerged in East Asia and spread around the world from December 2019. The most severe ... -
A systematic review involving 11,187 participants evaluating the impact of COVID-19 on anxiety and depression in pregnant women
(2020-09-23)Background: COVID-19 has started to spread within China since the end of December 2019. As a special population, the pregnant and delivery women maybe influenced both in physical and psychological aspects. The meta-analysis ... -
A systematic review and meta-analysis on chloroquine and hydroxychloroquine as monotherapy or combined with azithromycin in COVID-19 treatment
(2020-12-17)Many recent studies have investigated the role of either Chloroquine (CQ) or Hydroxychloroquine (HCQ) alone or in combination with azithromycin (AZM) in the management of the emerging coronavirus. This systematic review ... -
Echocardiographic Features of Cardiac Injury Related to COVID-19 and Their Prognostic Value: A Systematic Review
(2020-12-22)[Abstract]. Background: The available information on the echocardiographic features of cardiac injury related to the novel coronavirus disease 2019 (COVID-19) and their prognostic value are scattered in the different ... -
Remdesivir for the treatment of COVID-19: a living systematic review
(2020-12-09)Objective: Provide a timely, rigorous and continuously updated summary of the evidence on the role of remdesivir in the treatment of patients with COVID-19. Methods: Eligible studies were randomized trials evaluating the ...
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