Browsing Technical documents and research evidence on COVID-19 by Title
Now showing items 1005-1024 of 1749
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Modelling of Systemic versus Pulmonary Chloroquine Exposure in Man for COVID-19 Dose Selection
(2020-05-01)Chloroquine has attracted intense attention as a potential clinical candidate for prevention and treatment of COVID-19 based on reports of in-vitro efficacy against SARS-CoV-2. While the pharmacokinetic-pharmacodynamic ... -
Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations. Scientific brief, 27 March 2020
(2020-03-27)According to current evidence, COVID-19 virus is transmitted between people through respiratory droplets and contact routes. Droplet transmission occurs when a person is in in close contact (within 1 m) with someone who ... -
Modes of transmission of virus causing COVID-19:implications for IPC precaution recommendations. Scientific Brief, 29 March 2020
(2020-03-29)Modes of transmission of the COVID-19 virus: Respiratory infections can be transmitted through droplets of different sizes: when the droplet particles are >5-10 μm in diameter they are referred to as respiratory droplets, ... -
Modified telehealth for care of chronic wounds during the Coronavirus disease 2019 pandemic: A rapid literature review of alternative care modalities
(2020-09-09)Due to the changes in delivering medical care during the Coronavirus disease 2019 (COVID‐19) pandemic, such as the heavy reliance on telehealth, it is worth exploring if this is suitable when treating complex wounds. A ... -
Molecular Characterization of Three Zika Flaviviruses Obtained from Sylvatic Mosquitoes in the Central African Republic
(2014)Zika virus (ZIKV) is an emerging pathogen belonging to the Spondweni serocomplex within the genus Flavivirus. It has been isolated from several mosquito species. Two lineages of ZIKV have been defined by polyprotein homology. ... -
Molecular detection of SARS-CoV-2 using a reagent-free approach
(2020-05-02)Shortage of reagents and consumables required for the extraction and molecular detection of SARS-CoV-2 RNA in respiratory samples has led many laboratories to investigate alternative approaches for sample preparation. ... -
Molecular Evolution of Zika Virus during Its Emergence in the 20th Century
(2014)Zika virus (ZIKV) is a mosquito-borne flavivirus first isolated in Uganda in 1947. Although entomological and virologic surveillance have reported ZIKV enzootic activity in diverse countries of Africa and Asia, few human ... -
Molecular Mechanism of Evolution and Human Infection with SARS-CoV-2
(2020-04-10)The outbreak of a novel coronavirus, which was later formally named the severe acute respiratory coronavirus 2 (SARS-CoV-2), has caused a worldwide public health crisis. Previous studies showed that SARS-CoV-2 is highly ... -
Monitoring and evaluation framework. COVID‑19 strategic preparedness and response, 5 June 2020
(2020-06-05)Rationale: Collecting and analysing global and country response indicators against planned actions or processes is essential to ensure accountability and transparency in monitoring progress and identifying gaps. The COVID‑19 ... -
More than just smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis
(2020-05-08)Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on ... -
More than Pneumonia: Distinctive Features of SARS-Cov-2 Infection. From Autopsy Findings to Clinical Implications: A Systematic Review
(2020-10-23)Despite safety recommendations for the management of corpses with COVID-19 infection and the high number of deaths worldwide, the post-mortem investigation rate is extremely low as well as the scientific contributions ... -
Mortality from COVID-19 in 12 countries and 6 states of the United States
(2020-04-22)Importance: Reliable estimates of COVID-19 mortality are crucial to aid control strategies and to assess the effectiveness of interventions. Objective: Project COVID-19 mortality trends to October 1, 2020, in 12 countries ... -
Mortality in hospitalized patients with cancer and coronavirus disease 2019: A systematic review and meta‐analysis of cohort studies
(2020-12-30)Background: Heterogeneous evidence exists on the effect of coronavirus disease 2019 (COVID‐19) on the clinical outcomes of patients with cancer. Methods: A systematic review was performed using the Medline, Embase, and ... -
A Mouse Model of Zika Virus Pathogenesis
(2016-06)The ongoing Zika virus (ZIKV) epidemic and unexpected clinical outcomes, including Guillain-Barré syndrome and birth defects, has brought an urgent need for animal models. We evaluated infection and pathogenesis with ... -
Mucocutaneous Findings and Course in an Adult With Zika Virus Infection
(2016-07)Importance The Zika virus epidemic has been declared a public health emergency of international concern by the World Health Organization. We describe the mucocutaneous features and histologic correlation in a patient with ... -
A Multi-centre, Adaptive, Randomized, Double-Blind, PlaceboControlled Clinical Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Patients
This is a multi-centre, adaptive, randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of investigational therapeutic agents in combination with standard-of care for the treatment ... -
Multiple drivers of the COVID-19 spread: role of climate, international mobility, and region-specific conditions
(2020-04-24)The novel Coronavirus Disease 2019 (COVID-19) has spread quickly across the globe. Here, we evaluated the role of climate (temperature and precipitation), region-specific susceptibility (BCG vaccination, malaria infection, ... -
A multipurpose serological survey in Kenya. 2. Results of arbovirus serological tests
(1970)Arbovirus infections are of public health interest in East Africa, where a very widespread epidemic of o'nyong-nyong fever was reported in 1959-60 and where the threat of yellow fever, present in neighbouring areas such ... -
Multivariable prediction model of intensive care unit transfer and death: a French prospective cohort study of COVID-19 patients
(2020-05-08)Background: Prognostic factors of coronavirus disease 2019 (COVID-19) patients among European population are lacking. Our objective was to identify early prognostic factors upon admission to optimize the management of ... -
Myocardial characteristics as the prognosis for COVID-19 patients
(2020-05-09)Background Amid the crisis of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), front-line clinicians in collaboration with backstage medical researchers analyzed ...