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Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection
dc.contributor.author | Lin, Lu et al. | |
dc.date.accessioned | 2020-04-09T03:51:59Z | |
dc.date.available | 2020-04-09T03:51:59Z | |
dc.date.issued | 2020-04-02 | |
dc.identifier.uri | https://doi.org/10.1136/gutjnl-2020-321013 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/983 | |
dc.description.abstract | [Abstract]. Objective: To study the GI symptoms in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. Design: We analysed epidemiological, demographic, clinical and laboratory data of 95 cases with SARS-CoV-2 caused coronavirus disease 2019. Real-time reverse transcriptase PCR was used to detect the presence of SARS-CoV-2 in faeces and GI tissues. Results: Among the 95 patients, 58 cases exhibited GI symptoms of which 11 (11.6%) occurred on admission and 47 (49.5%) developed during hospitalisation. Diarrhoea (24.2%), anorexia (17.9%) and nausea (17.9%) were the main symptoms with five (5.3%), five (5.3%) and three (3.2%) cases occurred on the illness onset, respectively. A substantial proportion of patients developed diarrhoea during hospitalisation, potentially aggravated by various drugs including antibiotics. Faecal samples of 65 hospitalised patients were tested for the presence of SARS-CoV-2, including 42 with and 23 without GI symptoms, of which 22 (52.4%) and 9 (39.1%) were positive, respectively. Six patients with GI symptoms were subjected to endoscopy, revealing oesophageal bleeding with erosions and ulcers in one severe patient. SARS-CoV-2 RNA was detected in oesophagus, stomach, duodenum and rectum specimens for both two severe patients. In contrast, only duodenum was positive in one of the four non-severe patients. Conclusions: GI tract may be a potential transmission route and target organ of SARS-CoV-2. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Gastrointestinal Diseases | en_US |
dc.subject | Diarrhea | en_US |
dc.subject | Anorexia | en_US |
dc.subject | Nausea | en_US |
dc.title | Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection | en_US |
eihealth.country | Others | en_US |
eihealth.category | Clinical characterization and management | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | Gut | en_US |
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