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Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis
dc.contributor.author | Lippi G et al. Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona | |
dc.date.accessioned | 2020-03-18T16:30:29Z | |
dc.date.available | 2020-03-18T16:30:29Z | |
dc.date.issued | 2020-03-13 | |
dc.identifier.uri | https://doi.org/10.1016/j.cca.2020.03.022 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/450 | |
dc.description.abstract | BACKGROUND: Coronavirus disease 2019 (COVID-19) is a novel infectious disease with lack of established laboratory markers available to evaluate illness severity. In this study, we investigate whether platelet count could differentiate between COVID-19 patients with or without severe disease. Additionally, we evaluate if thrombocytopenia is associated with severe COVID-19. METHODS: An electronic search in Medline, Scopus and Web of Science was performed to identify studies reporting data on platelet count in COVID-19 patients. A meta-analysis was performed, with calculation of weighted mean difference (WMD) of platelet number in COVID-19 patients with or without severe disease and odds ratio (OR) of thrombocytopenia for severe form of COVID-19. RESULTS: Nine studies with 1779 COVID-19 patients, 399 (22.4%) with severe disease, were included in the meta-analysis. The pooled analysis revealed that platelet count was significantly lower in patients with more severe COVID-19 (WMD -31×109/L; 95% CI, from -35 to -29×109/L). A subgroup analysis comparing patients by survival, found an even lower platelet count was observed with mortality (WMD, -48×109/L; 95% CI, -57 to -39×109/L. In the four studies (n=1427) which reported data on rate of thrombocytopenia, a low platelet count was associated with over fivefold enhanced risk of severe COVID-19 (OR, 5.1; 95% CI, 1.8-14.6). CONCLUSIONS: Low platelet count is associated with increased risk of severe disease and mortality in patients with COVID-19, and thus should serve as clinical indicator of worsening illness during hospitalization. | en_US |
dc.title | Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis | en_US |
eihealth.country | Others | en_US |
eihealth.category | Clinical characterization and management | en_US |
eihealth.type | Published Article | en_US |
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