Browsing Technical documents and research evidence on COVID-19 by Subject "Remdesivir"
Now showing items 1-13 of 13
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Coronavirus disease 2019 (COVID-19) pandemic and pregnancy
(2020-03-23)The current coronavirus disease 2019 (COVID-19) pneumonia pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading globally at an accelerated rate, with a basic reproduction number ... -
Effect of remdesivir on patients with COVID-19: A network meta-analysis of randomized control trials
(2020-10-15)Several randomized controlled trials (RCTs) were conducted to investigate the effect of remdesivir for patients with COVID-19, but their results were conflicting. Thus, we conducted a network meta-analysis comparing the ... -
Efficacy and safety of remdesivir in hospitalized Covid‐19 patients: Systematic review and meta‐analysis including network meta‐analysis
(2020-10-31)Remdesivir is an antiviral agent that has shown broad‐spectrum activity, including against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Clinical trials investigating the role of remdesivir in coronavirus ... -
Exploring Repurposing Potential of Existing Drugs in the Management of COVID-19 Epidemic: A Critical Review
(2020-08)Despite high morbidity and mortality of ongoing coronavirus disease 2019 (COVID-19) pandemic, no specific therapy has been established till date. Though in vitro studies identified various molecules as possible therapies ... -
Impacts of remdesivir on dynamics and efficacy stratified by the severity of COVID- 19: a simulated two-arm controlled study
(2020-05-22)Background: The impact of remdesivir on length of stay of hospitalization, high-risk state, and death stratified by the severity of COVID-19 at enrollment is controversial. Methods: We applied a simulated two-arm controlled ... -
Ongoing Living Update of Potential COVID-19 Therapeutics Options: Summary of Evidence. Rapid Review
(2020-12-18)Summary of rapid systematic reviews, from the 8th edition of the document and above. -
Pharmacogenomics of COVID-19 therapies
(2020-08-18)A new global pandemic of coronavirus disease 2019 (COVID-19) has resulted in high mortality and morbidity. Currently numerous drugs are under expedited investigations without well-established safety or efficacy data. ... -
Remdesivir for the treatment of COVID-19: a living systematic review
(2020-12-09)Objective: Provide a timely, rigorous and continuously updated summary of the evidence on the role of remdesivir in the treatment of patients with COVID-19. Methods: Eligible studies were randomized trials evaluating the ... -
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial
(2020-04-29)Background: No specific antiviral drug has been proven effective for treatment of patients with severe coronavirus disease 2019 (COVID-19). Remdesivir (GS-5734), a nucleoside analogue prodrug, has inhibitory effects on ... -
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
(2020-04-13)Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Replication of SARS-CoV-2 depends ... -
Remdesivir: A potential game-changer or just a myth? A systematic review and meta-analysis
(2020-10-26)Aims: COVID-19 outbreak has created a public health catastrophe all over the world. Here, we have aimed to conduct a systematic review and meta-analysis on remdesivir use for COVID-19. Main methods: We searched Pubmed, ... -
Role of adjunctive treatment strategies in COVID-19 and a review of international and national clinical guidelines
(2020-05-05)The coronavirus disease (COVID-19) pandemic has led to a global struggle to cope with the sheer numbers of infected persons, many of whom require intensive care support or eventually succumb to the illness. The outbreak ... -
Systematic Review on the Therapeutic Options for COVID-19: Clinical Evidence of Drug Efficacy and Implications
(2020-12-29)A novel coronavirus-2 (SARS-CoV-2) was first identified in Wuhan, China, and quickly spread globally. Several treatments have been proposed, many of which have proven ineffective. Consequently, there is a need to review ...