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Adverse effects of non-steroidal anti-inflammatory drugs in patients with viral respiratory infections: rapid systematic review
(2020-11-19)Objectives: To assess the effects of non-steroidal anti-inflammatory drugs (NSAIDs) in patients with viral respiratory infections on acute severe adverse outcomes, healthcare utilisation, quality of life and long-term ... -
The Cardiac Toxicity of Chloroquine or Hydroxychloroquine in COVID-19 Patients: A Systematic Review and Meta-regression Analysis
(2020-10-19)Objective: To systematically review the literature and estimate the risk of Chloroquine (CQ) and hydroxychloroquine (HCQ) cardiac toxicity in COVID-19 patients. Methods: We searched multiple data sources including ... -
Characteristics of registered clinical trials assessing treatments for COVID-19: a cross-sectional analysis
(2020-06-09)Objectives The coronavirus disease 2019 (COVID-19) pandemic has prompted many initiatives to identify safe and efficacious treatments, yet little is known regarding where early efforts have focused. We aimed to characterise ... -
Charlson comorbidity index and a composite of poor outcomes in COVID-19 patients: A systematic review and meta-analysis
(2020-10-28)Background and aims: The ongoing COVID-19 pandemic is disproportionately affecting patients with comorbidities. Therefore, thorough comorbidities assessment can help establish risk stratification of patients with COVID-19, ... -
Children’s experiences of a parent’s stay in ICU
(2020-07-20)Citation: MacEachnie LH, Larsen HB, Egerod I. Children’s and young people’s experiences of a parent’s critical illness and admission to the intensive care unit: A qualitative meta-synthesis. Journal of Clinical Nursing. ... -
Chronology of COVID-19 cases on the Diamond Princess cruise ship and ethical considerations: a report from Japan
(2020-03-24)Fact: The Diamond Princess cruise ship has been anchored at the Yokohama port in Japan since February 3, 2020. A total of 691 cases of COVID-19 infection had been confirmed as of February 23. The government initially assumed ... -
Ethical guidance for disaster response
(2020-04-07)Citation: Leider JP, DeBruin D, Reynolds N, Koch A, Seaberg J. Ethical Guidance for Disaster Response, Specifically Around Crisis Standards of Care: A Systematic Review. American Journal of Public Health 2017; 107: e1–e9 What ... -
Ethics guidance on key issues raised by the novel coronavirus disease (COVID-19) pandemic, 16 March 2020
(2020-03-18)Health authorities are tasked with protecting the health of the population and responding to public health emergencies. An adequate health response to public health emergencies, such as the current WHO-declared COVID-19 ... -
The ethics of COVID-19 treatment studies: too many are open, too few are double-masked
(2020-06-30)A WHO panel, convened during the 2014 Ebola virus epidemic, assessed the ethical implications of using medicines that have shown promising results in the laboratory and in animal models, but before they have been evaluated ... -
Evaluating the Efficacy and Safety of the Existing Repurposed Pharmacological Agents for Treating COVID-19: A Meta-analysis and Systematic Review of Clinical Trials
(2020-11)Purpose: The present study systematically searched important medical databases, assessed the quality of available pieces of evidence, and performed a meta-analysis to test the efficacy of different therapeutic options ... -
Extracorporeal Treatment for Chloroquine, Hydroxychloroquine, and Quinine Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup
(2020-09-22)Background: Although chloroquine, hydroxychloroquine, and quinine are used for a range of medical conditions, recent research suggested a potential role in treating COVID-19. The resultant increase in prescribing was ... -
Frequency of Long QT in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine: A Meta-analysis
(2020-10-24)Introduction: Hydroxychloroquine (HCQ) has been proposed as a SARS-CoV-2 treatment but the frequency of long QT (LQT) during use is unknown. Objective: To conduct a meta-analysis of the frequency of LQT in patients with ... -
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
(2020-06-17)BACKGROUND: There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide ... -
Hydroxychloroquine safety: A meta-analysis of randomized controlled trials
(2020-07-06)Background: Hydroxychloroquine (HCQ) is currently being examined for COVID-19. No previous meta-analysis has evaluated its side effects versus placebo. We conducted this meta-analysis to compare the safety of HCQ versus ... -
Hydroxychloroquine: a potential ethical dilemma for rheumatologists during the COVID-19 pandemic
(2020-04)Two antimalarial agents, chloroquine (CQ) and hydroxychloroquine (HCQ), have been trusted treatments for a range of rheumatic diseases over the past seventy years [1]. These agents have attracted intense media attention ... -
Impact of Hydroxychloroquine on Mortality in Hospitalized Patients with COVID-19: Systematic Review and Meta-Analysis
(2020-11-05)Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused significant health and economic havoc around the globe. One of the early agents targeted for repurposing ... -
Insufficient etiological workup of COVID-19-associated acute pancreatitis: A systematic review
(2020-10-28)BACKGROUND. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, mostly causing respiratory symptoms, is also known to affect the gastrointestinal tract. Several case reports hypothesize that SARS-CoV-2 ... -
Interventions for people with disabilities in low‐and middle‐income countries: evidence and gap map
(2020-07-16)Citation: Saran A, White H, Kuper H. Evidence and gap map of studies assessing the effectiveness of interventions for people with disabilities in low‐and middle‐income countries. Campbell Systematic Reviews. 2020;16(1):e1070. ... -
Managing intensive care admissions when there are not enough beds during the COVID-19 pandemic: a systematic review
(2020-12-17)The surge in cases of severe COVID-19 has resulted in clinicians triaging intensive care unit (ICU) admissions in places where demand has exceeded capacity. In order to assist difficult triage decisions, clinicians require ...