Navegação Technical documents and research evidence on COVID-19 por título
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Transmission potential of Zika virus infection in the South Pacific
(2016-06)Objectives Zika virus has spread internationally through countries in the South Pacific and Americas. The present study aimed to estimate the basic reproduction number, R0, of Zika virus infection as a measurement of the ... -
Travel‐related control measures to contain the COVID‐19 pandemic: a rapid review
(2020-09-16)BackgroundIn: In late 2019, first cases of coronavirus disease 2019, or COVID-19, caused by the novel coronavirus SARS-CoV-2, were reported inWuhan, China. Subsequently COVID-19 spread rapidly around the world. To contain ... -
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
(2020-03-27)Importance: Coronavirus disease 2019 (COVID-19) is a pandemic with no specific therapeutic agents and substantial mortality. It is critical to find new treatments. Objective: To determine whether convalescent plasma ... -
Treatment of patients with non-severe and severe COVID-19: an evidence-based guideline
(2020)On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 viral disease a pandemic. The worldwide spread of coronavirus disease-2019 (COVID-19) represents a profound threat to human health. Patients with ... -
Treatment Response to Hydroxychloroquine, Lopinavir/Ritonavir, and Antibiotics for Moderate COVID 19: A First Report on the Pharmacological Outcomes from South Korea
(2020-06-14)The authors have withdrawn this manuscript because of the controversy about hydroxychloroquine and potential changes in results after peer-review, the authors intend to share their results in formal publication. Therefore, ... -
Treatment with ACE inhibitors or ARBs and risk of severe/lethal COVID-19: a meta-analysis
(2020-07-01)Objective It has been hypothesised that the use of ACE inhibitors and angiotensin receptor blockers (ARBs) might either increase or reduce the risk of severe or lethal COVID-19. The findings from the available observational ... -
Trends of SARS-CoV-2 infection worldwide: Role of population density, age structure, and climate on transmission and case fatality
(2020-05-22)Introduction The disease transmission pattern of COVID19 is highly heterogeneous, which suggests that the pandemic maybe driven by complex factors, which may include habitat suitability, region specific human mobility, and ... -
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19
(2020-03-18)BACKGROUND: No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2. METHODS: We conducted a randomized, controlled, open-label trial involving hospitalized adult patients ... -
A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
(2020-03-18)[Methods] We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes the respiratory illness Covid-19, and an oxygen saturation (Sao2 ) ... -
Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial
(2020-05-08)Background: Effective antiviral therapy is important for tackling the coronavirus disease 2019 (COVID-19) pandemic. We assessed the efficacy and safety of combined interferon beta-1b, lopinavir–ritonavir, and ribavirin for ... -
Twelve isolations of Zika virus from Aedes (Stegomyia) africanus
(1964)In continuation of a series of studies of arboreal mosquitos as virus vectors in Uganda, 12 strains of Zika virus and one strain of another Group B arbovirus were isolated between November 1961 and June 1963 from pools of ... -
Twenty-four cases of imported zika virus infections diagnosed by molecular methods
(2016)Zika virus is an emerging flavivirus widely spreading through Latin America. Molecular diagnosis of the infection can be performed using serum, urine and saliva samples, although a well-defined diagnostic algorithm is not ... -
Two cases of Zika fever imported from French Polynesia to Japan, December 2013 to January 2014
(2014)We report two cases of Zika fever in Japan, which were imported from French Polynesia, where on 6 November 2013 public health authorities reported an outbreak of subfebrile illness with rash due to Zika virus (ZIKV). The ... -
Two cases of Zika fever imported from French Polynesia to Japan, December 2013 to January 2014
(2014)We present two cases of imported Zika fever to Japan, in travellers returning from French Polynesia, where an outbreak due to Zika virus (ZIKV) is ongoing since week 41 of 2013. This report serves to raise awareness among ... -
Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection
(2016-06)During mammalian pregnancy, the placenta acts as a barrier between the maternal and fetal compartments. The recently observed association between Zika virus (ZIKV) infection during human pregnancy and fetal microcephaly ... -
U.S. county level analysis to determine If social distancing slowed the spread of COVID-19
(2020-06)[ABSTRACT]. Objective. To analyze the effectiveness of social distancing in the United States (U.S.). Methods. A novel cell-phone ping data was used to quantify the measures of social distancing by all U.S. counties. ...