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Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses
dc.contributor.author | Song, H | |
dc.contributor.author | Haywood, Qi J | |
dc.contributor.author | J Shi, Y | |
dc.date.accessioned | 2022-09-04T15:15:23Z | |
dc.date.available | 2022-09-04T15:15:23Z | |
dc.date.issued | 2016-06 | |
dc.identifier.uri | https://www.nature.com/nsmb/articles#affil-auth | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/2929 | |
dc.description.abstract | The association of Zika virus (ZIKV) infections with microcephaly has resulted in an ongoing public-health emergency. Here we report the crystal structure of a C-terminal fragment of ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion. Comparison with West Nile and dengue virus NS1 structures reveals conserved features but diverse electrostatic characteristics at host-interaction interfaces, thus possibly implying different modes of flavivirus pathogenesis. | en_US |
dc.language | English | en_US |
dc.subject | Zika Research Project | en_US |
dc.subject | Zika Virus | en_US |
dc.subject | Zika Virus Infection | en_US |
dc.subject | Flavivirus | en_US |
dc.subject | Microcephaly | en_US |
dc.title | Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses | en_US |
eihealth.country | Others | en_US |
eihealth.category | Epidemiology and epidemiological studies | en_US |
eihealth.type | Research protocol information | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | Nature | en_US |
dc.contributor.corporatename | China. Chinese Academy of Sciences | en_US |
dc.contributor.corporatename | Shenzhen Third People's Hospital | en_US |
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