dc.contributor.author | Dai, Lianpan | |
dc.contributor.author | Song, Jian | |
dc.contributor.author | Lu, Xishan | |
dc.contributor.author | et al. | |
dc.date.accessioned | 2022-09-04T02:47:40Z | |
dc.date.available | 2022-09-04T02:47:40Z | |
dc.date.issued | 2016-06 | |
dc.identifier.uri | https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(16)30149-4#%20 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/2877 | |
dc.description.abstract | Zika virus (ZIKV), a mosquito-borne flavivirus, is a current global public health concern. The flavivirus envelope (E) glycoprotein is responsible for virus entry and represents a major target of neutralizing antibodies for other flaviviruses. Here, we report the structures of ZIKV E protein at 2.0 Å and in complex with a flavivirus broadly neutralizing murine antibody 2A10G6 at 3.0 Å. ZIKV-E resembles all the known flavivirus E structures but contains a unique, positively charged patch adjacent to the fusion loop region of the juxtaposed monomer, which may influence host attachment. The ZIKV-E-2A10G6 complex structure reveals antibody recognition of a highly conserved fusion loop. 2A10G6 binds to ZIKV-E with high affinity in vitro and neutralizes currently circulating ZIKV strains in vitro and in mice. The E protein fusion loop epitope represents a potential candidate for therapeutic antibodies against ZIKV. | en_US |
dc.language | English | en_US |
dc.subject | Zika Research Project | en_US |
dc.subject | Zika Virus | en_US |
dc.subject | Flavivirus | en_US |
dc.title | Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody | en_US |
eihealth.country | Others | en_US |
eihealth.category | Epidemiology and epidemiological studies | en_US |
eihealth.type | Research protocol information | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | Cell Host & Microbe | en_US |
dc.contributor.corporatename | Chinese Academy of Sciences. Beijing Institutes of Life Science. Network of Immunity and Health (RNIH) | en_US |
dc.contributor.corporatename | Chinese Academy of Sciences. Institute of Microbiology. Key Laboratory of Pathogenic Microbiology and Immunology | en_US |
dc.contributor.corporatename | University of Chinese Academy of Sciences. Savaid Medical School | en_US |