dc.contributor.author | Hariyanto, Timotius Ivan | |
dc.contributor.author | Japar, Karunia Valeriani | |
dc.contributor.author | Kwenandar, Felix | |
dc.contributor.author | Damay, Vika | |
dc.contributor.author | Siregar, Jeremia Immanuel | |
dc.contributor.author | Lugito, Nata Pratama Hardjo | |
dc.contributor.author | Tjiang, Margaret Merlyn | |
dc.contributor.author | Kurniawan, Andree | |
dc.date.accessioned | 2021-03-19T20:42:57Z | |
dc.date.available | 2021-03-19T20:42:57Z | |
dc.date.issued | 2020-12-30 | |
dc.identifier.uri | https://doi.org/10.1016/j.ajem.2020.12.076 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/2538 | |
dc.description.abstract | Background: Laboratory testing is commonly performed in patients with COVID-19. Each of the laboratory parameters has potential value for risk stratification and prediction of COVID-19 outcomes. This systematic review and meta-analysis aimed to evaluate the difference between these parameters in severe and nonsevere disease and to provide the optimal cutoff value for predicting severe disease. Method: We performed a systematic literature search through electronic databases. The variables of interest were serum procalcitonin, albumin, C-reactive protein (CRP), D-dimer, and lactate dehydrogenase (LDH) levels in each group of severity outcomes from COVID-19. Results: There were a total of 4848 patients from 23 studies. Our meta-analysis suggest that patients with severe COVID-19 infections have higher procalcitonin, (mean difference 0.07; 95% CI 0.05–0.10; p < 0.00001), CRP (mean difference 36.88; 95% CI 29.10–44.65; p < 0.00001), D-Dimer (mean difference 0.43; 95% CI 0.31–0.56; p < 0.00001), and LDH (mean difference 102.79; 95% CI 79.10–126.49; p < 0.00001) but lower levels of albumin (mean difference −4.58; 95% CI −5.76 to −3.39; p < 0.00001) than those with nonsevere COVID-19 infections. The cutoff values for the parameters were 0.065 ng/mL for procalcitonin, 38.85 g/L for albumin, 33.55 mg/L for CRP, 0.635 μ/L for D-dimer, and 263.5 U/L for LDH, each with high sensitivity and specificity. Conclusion: This meta-analysis suggests elevated procalcitonin, CRP, D-dimer, and LDH and decreased albumin can be used for predicting severe outcomes in COVID-19. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Coronavirus Infections | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | Laboratories | en_US |
dc.title | Inflammatory and hematologic markers as predictors of severe outcomes in COVID-19 infection: A systematic review and meta-analysis | en_US |
eihealth.country | Others | en_US |
eihealth.category | Clinical characterization and management | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | The American Journal of Emergency Medicine | en_US |