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Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19
dc.contributor.author | Liu, Fang et al. | |
dc.date.accessioned | 2020-09-28T14:44:26Z | |
dc.date.available | 2020-09-28T14:44:26Z | |
dc.date.issued | 2020-04-14 | |
dc.identifier.uri | https://doi.org/10.1016/j.jcv.2020.104370 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/2268 | |
dc.description.abstract | Background: The inflammatory response plays a critical role in coronavirus disease 2019 (COVID-19), and inflammatory cytokine storm increases the severity of COVID-19. Objective: To investigate the ability of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) to predict mild and severe cases of COVID-19. Study design: This retrospective cohort study included 140 patients diagnosed with COVID-19 from January 18, 2020, to March 12, 2020. The study population was divided into two groups according to disease severity: a mild group (MG) (n = 107) and a severe group (SG) (n = 33). Data on demographic characteristics, baseline clinical characteristics, and the levels of IL-6, CRP, and PCT on admission were collected. Results: Among the 140 patients, the levels of IL-6, CRP, and PCT increased in 95 (67.9 %), 91 (65.0 %), and 8 (5.7 %) patients on admission, respectively. The proportion of patients with increased IL-6, CRP, and PCT levels was significantly higher in the SG than in the MG. Cox proportional hazard model showed that IL-6 and CRP could be used as independent factors to predict the severity of COVID-19. Furthermore, patients with IL-6 > 32.1 pg/mL or CRP > 41.8 mg/L were more likely to have severe complications. Conclusion: The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Coronavirus Infections | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Interleukin-6 | en_US |
dc.subject | C-Reactive Protein | en_US |
dc.subject | Procalcitonin | en_US |
dc.subject | Prognosis | en_US |
dc.title | Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19 | en_US |
eihealth.country | Others | en_US |
eihealth.category | Clinical characterization and management | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | Journal of Clinical Virology | en_US |
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