Efficacy and safety of umifenovir for coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
Huang, Dong et al.
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Background: We conducted this systemic review and meta‐analysis in an attempt to evaluate the efficacy and safety of umifenovir in COVID‐19. Methods: We searched PubMed, Web of Science, Embase, Cochrane Library, CNKI and medRxiv database. We included both retrospective and prospective studies. The mean difference (MD) and risk ratio (RR) with 95% confidence intervals (CI) were applied to assess the effectiveness of umifenovir for COVID‐19. Results: A total of 12 studies with 1052 patients were included in our final studies. Compared with control group, umifenovir is associated with higher negative rate of PCR on day 14 (RR:1.27; 95% CI: 1.04 to 1.55). However, umifenovir is not related to nucleus acid negative conversion time(MD: 0.09; 95% CI: ‐1.48 to 1.65), negative rate on day 7(RR:1.09; 95% CI: 0.91 to 1.31), incidence of composite endpoint (RR:1.20; 95% CI: 0.61 to 2.37), rate of fever alleviation on day 7 (RR:1.00; 95% CI: 0.91 to 1.10), rate of cough alleviation on day 7 (RR:1.00; 95% CI: 0.85 to 1.18), or hospital length of stay (LOS) (MD: 1.34; 95% CI: ‐2.08 to 4.76). Additionally, umifenovir was safe in COVID‐19 patients (RR for incidence of adverse events:1.29; 95% CI: 0.57 to 2.92). The results of sensitivity analysis and subgroup analysis were similar to pooled results. Conclusions: There is no evidence to support the use of umifenovir for improving patient‐important outcomes in patients with COVID‐19.