Browsing Resources in English by Subject "Lopinavir"
Now showing items 1-17 of 17
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Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19
(2020-03-30)Lopinavir/ritonavir and arbidol have been previously used to treat acute respiratory syndrome- coron- avirus 2 (SARS-CoV-2) replication in clinical practice; nevertheless, their effectiveness remains controver- sial. In ... -
The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients
(2020-03-29)Objective:This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People’s Hospital, enrolled from Jan 5 to Feb ... -
COVID-19: A Brief Overview of the Discovery Clinical Trial
(2020-04-10)COVID-19 (coronavirus disease 2019) is a worldwide outbreak of pneumonia and acute respiratory distress syndrome. It is unambiguously linked to the human–human transmission of a novel coronavirus. Mutagenomic analyses ... -
Efficacy of chloroquine versus lopinavir/ritonavir in mild/general COVID-19 infection: a prospective, open-label, multicenter, randomized controlled clinical study
(2020-07-08)Background: The outbreak of COVID-19 (caused by SARS-Cov-2) is very serious, and no effective antiviral treatment has yet been confirmed. The adage “old drug, new trick” in this context may suggest the important therapeutic ... -
Efficacy of Lopinavir/Ritonavir Compared With Standard Care for Treatment of Coronavirus Disease 2019 (COVID-19): A Systematic Review
(2020-10-29)Background: Coronavirus disease 2019 (COVID-19) is a newly discovered multi-organ disease caused by the novel coronavirus SARS-CoV-2. Currently, there are no official guidelines on the pharmacological treatment of COVID-19. ... -
Evaluating the Efficacy and Safety of the Existing Repurposed Pharmacological Agents for Treating COVID-19: A Meta-analysis and Systematic Review of Clinical Trials
(2020-11)Purpose: The present study systematically searched important medical databases, assessed the quality of available pieces of evidence, and performed a meta-analysis to test the efficacy of different therapeutic options ... -
Lopinavir-ritonavir alone or combined with arbidol in the treatment of 73 hospitalized patients with COVID-19: a pilot retrospective study
(2020-04-29)Objectives: This study aimed to evaluate the antiviral efficacy of lopinavir/ritonavir alone or combined with arbidol in the treatment of hospitalized patients with common coronavirus disease-19 (COVID-19). Methods: In ... -
Lopinavir-ritonavir for COVID-19: A living systematic review
(2020-07-15)Objective: Provide a timely, rigorous, and continuously updated summary of the evidence on the role of lopinavir/ritonavir in the treatment of patients with COVID-19. Methods: We conducted searches in the special L·OVE ... -
Lopinavir/ritonavir: A rapid review of effectiveness in COVID-19
(2020-04-14)There are currently no pharmacological treatments for COVID-19. Due to the urgent need for effective treatments, there has been increased interest in re-purposing currently available drugs for immediate use. The antiretroviral ... -
Ongoing Living Update of Potential COVID-19 Therapeutics Options: Summary of Evidence. Rapid Review
(2020-12-18)Summary of rapid systematic reviews, from the 8th edition of the document and above. -
Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression.
(2020-03-06)OBJECTIVES: To explore the epidemiological information, clinical characteristics, therapeutic outcomes and temporal progression of laboratory findings in 2019-coronavirus disease (COVID-19) patients exposed to lopinavir. ... -
Plasma concentration and safety of lopinavir/ritonavir in patients with Covid-19: a retrospective cohort study
(2020-05-22)Background: There is an urgent need of active treatment for coronavirus disease 2019 (Covid-19). Although efficacy have not been proven, lopinavir/ritonavir 400 mg/100 mg twice daily has been proposed as a treatment of ... -
Role of adjunctive treatment strategies in COVID-19 and a review of international and national clinical guidelines
(2020-05-05)The coronavirus disease (COVID-19) pandemic has led to a global struggle to cope with the sheer numbers of infected persons, many of whom require intensive care support or eventually succumb to the illness. The outbreak ... -
Systematic Review on the Therapeutic Options for COVID-19: Clinical Evidence of Drug Efficacy and Implications
(2020-12-29)A novel coronavirus-2 (SARS-CoV-2) was first identified in Wuhan, China, and quickly spread globally. Several treatments have been proposed, many of which have proven ineffective. Consequently, there is a need to review ... -
Treatment Response to Hydroxychloroquine, Lopinavir/Ritonavir, and Antibiotics for Moderate COVID 19: A First Report on the Pharmacological Outcomes from South Korea
(2020-06-14)The authors have withdrawn this manuscript because of the controversy about hydroxychloroquine and potential changes in results after peer-review, the authors intend to share their results in formal publication. Therefore, ... -
A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
(2020-03-18)[Methods] We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes the respiratory illness Covid-19, and an oxygen saturation (Sao2 ) ... -
Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial
(2020-05-08)Background: Effective antiviral therapy is important for tackling the coronavirus disease 2019 (COVID-19) pandemic. We assessed the efficacy and safety of combined interferon beta-1b, lopinavir–ritonavir, and ribavirin for ...