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COVID-19 in healthcare workers in three hospitals in the South of the Netherlands, March 2020
dc.contributor.author | Sikkema, Reina S et al. | |
dc.date.accessioned | 2020-06-01T12:28:20Z | |
dc.date.available | 2020-06-01T12:28:20Z | |
dc.date.issued | 2020-05-01 | |
dc.identifier.uri | https://doi.org/10.1101/2020.04.26.20079418 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/1652 | |
dc.description.abstract | Background: Ten days after the first reported case of SARS-CoV-2 infection in the Netherlands, 3.9% of healthcare workers (HCWs) in nine hospitals located in the South of the Netherlands tested positive for SARS-CoV-2 RNA. The extent of nosocomial transmission that contributed to the HCW infections was unknown. Methods: We combined epidemiological data, collected by means of structured interviews of HCWs, with whole genome sequencing (WGS) of SARS-CoV-2 in clinical samples from HCWs and patients in three of nine hospitals that participated in the HCW screening, to perform an in-depth analysis of sources and modes of transmission of SARS -CoV-2 in HCWs and patients. Results: A total of 1,796 out of 12,022 HCWs (15%) of the three participating hospitals were screened, based on clinical symptoms, of whom 96 (5%) tested positive for SARS-CoV-2. We obtained complete genome sequences of 50 HCWs and 18 patients. Most sequences grouped in 3 clusters, with 2 clusters displaying local circulation within the region. The observed patterns are most consistent with multiple introductions into the hospitals through community acquired infections, and local amplification in the community. Conclusions: Although direct transmission in the hospitals cannot be ruled out, the data does not support widespread nosocomial transmission as source of infection in patients or healthcare workers. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Health Personnel | en_US |
dc.subject | Health Care | en_US |
dc.subject | Netherlands | en_US |
dc.subject | SARS-CoV | en_US |
dc.subject | Betacoronavirus | en_US |
dc.title | COVID-19 in healthcare workers in three hospitals in the South of the Netherlands, March 2020 | en_US |
eihealth.country | Global (WHO/OMS) | en_US |
eihealth.category | Epidemiology and epidemiological studies | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Slow Spread / Reducir la Dispersión | en_US |
dc.relation.ispartofjournal | medRxiv | en_US |
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