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dc.contributor.authorCadnum, Jennifer L. et al.
dc.description.abstractBackground: Shortages of personal protective equipment (PPE) including N95 filtering facepiece respirators is an urgent concern in the setting of the global COVID-19 pandemic. Decontamination of PPE could be useful to maintain adequate supplies, but there is uncertainty regarding the efficacy of decontamination technologies. Methods: A modification of the American Society for Testing and Materials standard quantitative carrier disk test method (ASTM E-2197-11) was used to examine the effectiveness of ultraviolet-C (UV-C) light, a high-level disinfection cabinet that generates aerosolized peracetic acid and hydrogen peroxide, and dry heat at 70°C for 30 minutes for decontamination of bacteriophages Phi6 and MS2 and methicillin-resistant Staphylococcus aureus (MRSA) inoculated onto 3 commercial N95 respirators. Three and 6 log10 reductions on N95 respirators were considered effective for decontamination and disinfection, respectively. Results: UV-C administered as a 1-minute cycle in a UV-C box or a 30-minute cycle by a room decontamination device reduced contamination but did not meet criteria for decontamination of the viruses from all sites for any of the N95s. The high-level disinfection cabinet was effective for decontamination of all the organisms from the N95s and achieved disinfection with 3 disinfection cycles over ~60 minutes. Dry heat at 70°C for 30 minutes was not effective for decontamination of the bacteriophages. Conclusions: UV-C could be useful to reduce contamination on N95 respirators. However, the UV-C technologies studied did not meet our criteria for decontamination under the test conditions used. The high-level disinfection cabinet was effective for decontamination of N95s and met criteria for disinfection with multiple cycles.en_US
dc.subjectInfectious Diseasesen_US
dc.subjectRespiratory Protective Devicesen_US
dc.subjectPeracetic Aciden_US
dc.subjectUltraviolet Raysen_US
dc.titleEffectiveness of Ultraviolet-C Light and a High-Level Disinfection Cabinet for Decontamination of N95 Respiratorsen_US
eihealth.categoryInfection prevention and control, including health care workers protectionen_US
eihealth.typePublished Articleen_US
eihealth.maincategoryProtect Health Care Workers / Proteger la Salud de los Trabajadoresen_US
dc.relation.ispartofjournalPathogens and Immunityen_US

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