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Incidence of thrombotic complications in critically ill ICU patients with COVID-19
dc.contributor.author | Kloka, F.A., et al. | |
dc.date.accessioned | 2020-05-04T19:20:20Z | |
dc.date.available | 2020-05-04T19:20:20Z | |
dc.date.issued | 2020-04 | |
dc.identifier.uri | https://doi.org/10.1016/j.thromres.2020.04.013 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/1294 | |
dc.description.abstract | Introduction: COVID-19 may predispose to both venous and arterial thromboembolism due to excessive in- flammation, hypoxia, immobilisation and diffuse intravascular coagulation. Reports on the incidence of thrombotic complications are however not available. Methods: We evaluated the incidence of the composite outcome of symptomatic acute pulmonary embolism (PE), deep-vein thrombosis, ischemic stroke, myocardial infarction or systemic arterial embolism in all COVID- 19 patients admitted to the ICU of 2 Dutch university hospitals and 1 Dutch teaching hospital. Results: We studied 184 ICU patients with proven COVID-19 pneumonia of whom 23 died (13%), 22 were discharged alive (12%) and 139 (76%) were still on the ICU on April 5th 2020. All patients received at least standard doses thromboprophylaxis. The cumulative incidence of the composite outcome was 31% (95%CI 20- 41), of which CTPA and/or ultrasonography confirmed VTE in 27% (95%CI 17-37%) and arterial thrombotic events in 3.7% (95%CI 0-8.2%). PE was the most frequent thrombotic complication (n = 25, 81%). Age (ad- justed hazard ratio (aHR) 1.05/per year, 95%CI 1.004-1.01) and coagulopathy, defined as spontaneous pro- longation of the prothrombin time > 3 s or activated partial thromboplastin time > 5 s (aHR 4.1, 95%CI 1.9- 9.1), were independent predictors of thrombotic complications. Conclusion: The 31% incidence of thrombotic complications in ICU patients with COVID-19 infections is re- markably high. Our findings reinforce the recommendation to strictly apply pharmacological thrombosis pro- phylaxis in all COVID-19 patients admitted to the ICU, and are strongly suggestive of increasing the prophylaxis towards high-prophylactic doses, even in the absence of randomized evidence. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Thrombosis | en_US |
dc.subject | Pulmonary Embolism | en_US |
dc.subject | Venous Thrombosis | en_US |
dc.subject | Stroke | en_US |
dc.title | Incidence of thrombotic complications in critically ill ICU patients with COVID-19 | en_US |
eihealth.country | Others | en_US |
eihealth.category | Clinical characterization and management | en_US |
eihealth.type | Other publications | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | Thrombosis Research | en_US |
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