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Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan
dc.contributor.author | Li, Xiaochen, et al. | |
dc.date.accessioned | 2020-05-01T23:07:58Z | |
dc.date.available | 2020-05-01T23:07:58Z | |
dc.date.issued | 2020 | |
dc.identifier.uri | https://doi.org/10.1016/j.jaci.2020.04.006 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/1271 | |
dc.description.abstract | Background: In December 2019, the coronavirus disease 2019 (COVID-19) outbreak occurred in Wuhan. Data on the clinical characteristics and outcomes of patients with severe COVID-19 are limited. Objective: We sought to evaluate the severity on admission, complications, treatment, and outcomes of patients with COVID-19. Methods: Patients with COVID-19 admitted to Tongji Hospital from January 26, 2020, to February 5, 2020, were retrospectively enrolled and followed-up until March 3, 2020. Potential risk factors for severe COVID-19 were analyzed by a multivariable binary logistic model. Cox proportional hazard regression model was used for survival analysis in severe patients. Results: We identified 269 (49.1%) of 548 patients as severe cases on admission. Older age, underlying hypertension, high cytokine levels (IL-2R, IL-6, IL-10, and TNF-a), and high lactate dehydrogenase level were significantly associated with severe COVID-19 on admission. The prevalence of asthma in patients with COVID-19 was 0.9%, markedly lower than that in the adult population of Wuhan. The estimated mortality was 1.1% in nonsevere patients and 32.5% in severe cases during the average 32 days of follow-up period. Survival analysis revealed that male sex, older age, leukocytosis, high lactate dehydrogenase level, cardiac injury, hyperglycemia, and high- dose corticosteroid use were associated with death in patients with severe COVID-19. Conclusions: Patients with older age, hypertension, and high lactate dehydrogenase level need careful observation and early intervention to prevent the potential development of severe COVID-19. Severe male patients with heart injury, hyperglycemia, and high-dose corticosteroid use may have a high risk of death. | en_US |
dc.language | English | en_US |
dc.subject | Risk Factors | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | Mortality | en_US |
dc.title | Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan | en_US |
eihealth.country | Others | en_US |
eihealth.category | Clinical characterization and management | en_US |
eihealth.type | Other publications | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | The Journal of Allergy and Clinical Immunology | en_US |
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