Browsing by Subject "Drug Therapy"
Now showing items 1-20 of 77
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Almitrine as a non ventilatory strategy to improve intrapulmonary shunt in COVID-19 patients
(2020-05-22)In severe COVID-19 pulmonary failure, hypoxia is mainly related to pulmonary vasodilation with altered hypoxic pulmonary vasoconstriction (HPV). Besides prone positioning, other non-ventilatory strategies may reduce the ... -
Assessment of Hydroxychloroquine and Chloroquine Safety Profiles: A Systematic Review and Meta-Analysis
(2020-05-08)Background: Recently, chloroquine (CQ) and its derivative hydroxychloroquine (HCQ) have emerged as potential antiviral and immunomodulatory options for the treatment of 2019 coronavirus disease (COVID-19). To examine the ... -
Association of active oncologic treatment and risk of death in cancer patients with COVID-19: a systematic review and meta-analysis of patient data
(2020-11-02)Background: Cancer patients suffer from worse coronavirus disease-2019 (COVID-19) outcomes. Whether active oncologic treatment is an additional risk factor in this population remains unclear. Therefore, here we have conducted ... -
Concentration-dependent mortality of chloroquine in overdose
(2020-04-29)Background: Hydroxychloroquine and chloroquine have been used extensively in malaria and rheumatological conditions. Although generally safe and well tolerated they are potentially lethal in overdose. These two drugs are ... -
Dexametasona para tratamento de pacientes infectados pelo SARS-CoV-2
(2020-07)Indicação na bula: Tratamento de condições nas quais os efeitos anti-inflamatórios e imunossupressores dos corticosteroides são desejados, especialmente para tratamento intensivo durante períodos mais curtos. Pergunta: ... -
Diretrizes para diagnóstico e tratamento da COVID-19. Sumário das recomendações: versão 4 (06 de maio de 2020)
(2020-05-06)Este documento apresenta as principais recomendações realizadas na Diretrizes para Diagnóstico e Tratamento da COVID-19, Versão 4 de 06 de maio de 2020. -
Diretrizes para diagnóstico e tratamento da COVID-19: versão 4 (07 de maio de 2020)
(2020-05-07)A elaboração das Diretrizes para Diagnóstico e Tratamento da COVID-19 é uma resposta rápida ao enfrentamento da COVID-19, diante da declaração de pandemia pela Organização Mundial de Saúde (OMS) e das iniciativas do ... -
Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis
(2020-05-06)Background: Severe acute respiratory syndrome coronavirus 2 (SARS−CoV−2) has been declared a global pandemic by the World Health Organisation and urgent treatment and prevention strategies are needed. Many clinical trials ... -
Effect of remdesivir on patients with COVID-19: A network meta-analysis of randomized control trials
(2020-10-15)Several randomized controlled trials (RCTs) were conducted to investigate the effect of remdesivir for patients with COVID-19, but their results were conflicting. Thus, we conducted a network meta-analysis comparing the ... -
Effectiveness and Safety of Glucocorticoids to Treat COVID-19: A Rapid Review and Meta-Analysis
(2020-04-22)Background: Glucocorticoids are widely used in the treatment of various pulmonary inflammatory diseases, but they are also often accompanied by significant adverse reactions. Published guidelines point out that low dose ... -
Effectiveness of Intravenous Immunoglobulin for Children with Severe COVID-19: A Rapid Review
(2020-04-22)Background: Intravenous immunoglobulin (IVIG) is usually used as supportive therapy, but the treatment of COVID-19 by IVIG is controversial. This rapid review aims to explore the clinical effectiveness and safety of IVIG ... -
Efficacy of remdesivir in COVID-19 patients with a simulated two-arm controlled study
(2020-05-08)While the recent study on the compassionate use of remdesivir for COVID-19 patients has shown a 68% clinical improvement7 it is a one-arm study that renders the evaluation of the efficacy in reducing death and the length ... -
Exploring Repurposing Potential of Existing Drugs in the Management of COVID-19 Epidemic: A Critical Review
(2020-08)Despite high morbidity and mortality of ongoing coronavirus disease 2019 (COVID-19) pandemic, no specific therapy has been established till date. Though in vitro studies identified various molecules as possible therapies ... -
Favipiravir para tratamento de pacientes com Covid-19. Agosto de 2020
(2020-08)Esta nota técnica tem por objetivo apresentar revisão rápida da literatura sobre a eficácia e a segurança do medicamento favipiravir no tratamento de pacientes com COVID-19. -
Hydroxychloroquine and azithromycin plus zinc vs hydroxychloroquine and azithromycin alone: outcomes in hospitalized COVID-19 patients
(2020-05-08)Background: COVID-19 has rapidly emerged as a pandemic infection that has caused significant mortality and economic losses. Potential therapies and means of prophylaxis against COVID-19 are urgently needed to combat this ... -
Hydroxychloroquine application is associated with a decreased mortality in critically ill patients with COVID-19
(2020-05-01)Importance: Coronavirus disease 2019 (COVID-19) is a pandemic with no specific drugs and high mortality. The most urgent thing is to find effective treatments. Objective: To determine whether hydroxychloroquine application ... -
Hydroxychloroquine in COVID-19: A systematic review and meta-analysis
(2020-05-20)Abstract Background Hydroxychloroquine is being administered among patients with COVID19 infection in many healthcare systems across the world considering its in vitro effect against the SARS CoV 2 virus. In spite of several ... -
Informe diário de evidências Covid-19 N° 18: busca realizada em 28 de abril de 2020
(2020-04-28)Essa é uma produção do Departamento de Ciência e Tecnologia (Decit) da Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos em Saúde (SCTIE) do Ministério da Saúde (Decit/SCTIE/MS), que tem como missão promover ... -
Informe diário de evidências Covid-19 N° 22: busca realizada entre 1° e 4 de maio de 2020
(2020-05)Essa é uma produção do Departamento de Ciência e Tecnologia (Decit) da Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos em Saúde (SCTIE) do Ministério da Saúde (Decit/SCTIE/MS), que tem como missão promover ... -
Informe diário de evidências COVID-19 Nº 13: busca realizada em 21 de abril de 2020
(2020-04-21)Apresentação: Essa é uma produção do Departamento de Ciência e Tecnologia (Decit) da Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos em Saúde (SCTIE) do Ministério da Saúde (Decit/SCTIE/MS), que tem como ...