Browsing by Subject "Antibodies"
Now showing items 1-17 of 17
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Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019
(2020-05-28)Background: The novel coronavirus SARS-CoV-2 is a newly emerging virus. The antibody response in infected patients remains largely unknown, and the clinical value of antibody testing has not been fully demonstrated. Methods: ... -
Bounding the Predictive Values of COVID-19 Antibody Tests
(2020-05-17)COVID-19 antibody tests have imperfect accuracy. There has been lack of clarity on the meaning of reported rates of false positives and false negatives. For risk assessment and clinical decision making, the rates of interest ... -
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
(2020-03-27)Since 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks, SARS-CoV in 2002–2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late 2019. However, little is currently known about the biology of ... -
Controlled Avalanche: A Regulated Voluntary Exposure Approach for Addressing Covid19
(2020-04-22)Background: The ongoing Covid-19 pandemic has driven many countries to take radical suppression measures. While reducing mortality, these measures result in severe economic repercussions, and inhibit the development of ... -
COVID-19: Roche Antibody Test – 14th May
(2020-05-14)What do sensitivity and specificity tell us? Sensitivity tells us the proportion of people who test positive, out of the population who should have tested positive. In this case, a sensitivity of 100% tells us that everybody ... -
The Dynamic Changes of Antibodies against SARS-CoV-2 during the Infection and Recovery of COVID-19
(2020-05-21)Deciphering the dynamic changes of antibodies against SARS-CoV-2 is essential for understanding the immune response in COVID-19 patients. By comprehensively analyzing the laboratory findings of 1,850 patients, we describe ... -
Early experiences with antibody testing in a Flemish nursing home during an acute COVID-19 outbreak: a retrospective cohort study
(2020-05-22)objectives: to assess the prevalence of COVID-19 (PCR-test) in residents and staff of a nursing home. To examine the presence of IgM and IgG antibodies in the sample and the relation between PCR and antibody test results. ... -
Early viral clearance and antibody kinetics of COVID-19 among asymptomatic carriers.
(2020-05-02)Background Asymptomatic carriers contribute to the spread of Coronavirus Disease 2019 (COVID-19), but their clinical characteristics, viral kinetics, and antibody responses remain unclear. Methods A total of 56 COVID-19 ... -
High seroreactivity against SARS-CoV-2 Spike epitopes in a pre SARS-CoV-2 cohort: implications for antibody testing and vaccine design
(2020-05-22)Little is known about the quality of polyclonal antibody responses in COVID-19 patients, and how it correlates with disease severity or patients' prior exposure to other pathogens. The whole polyclonal antibody repertoire ... -
Immunity Passports for SARS-CoV-2: an online experimental study of the impact of antibody test terminology on perceived risk and behaviour
(2020-05-10)Objective: To assess the impact of describing an antibody-positive test result using the terms Immunity and Passport or Certificate, alone or in combination, on perceived risk of becoming infected with SARS-CoV-2 and ... -
Informe diário de evidências Covid-19 Nº 87: busca realizada em 5 de agosto de 2020
(2020-08-05)Apresentação: O Informe Diário de Evidências é uma produção do Ministério da Saúde que tem como objetivo acompanhar diariamente as publicações científicas sobre tratamento farmacológico e vacinas para a COVID-19. Dessa ... -
Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies and public health implications
(2020-05-08)Serology-based tests have become a key public health element in the COVID-19 pandemic to assess the degree of herd immunity that has been achieved in the population. These tests differ between one another in several ways. ... -
The production of antibodies for SARS-CoV-2 and its clinical implication
(2020-04-24)Background: Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), a novel betacoronavirus, has caused an outburst of pneumonia cases in Wuhan, China. We report the production of specific IgM and IgG antibodies after ... -
Repeated population-based surveys of antibodies against SARS-CoV-2 in Southern Brazil
(2020-05-10)Population based data on COVID-19 are urgently needed for informing policy decisions, yet few such studies are available anywhere, as most surveys rely on self-selected volunteers. In the Brazilian State of Rio Grande do ... -
A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
(2020-09-17)Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount ... -
Ultra-Sensitive High-Resolution Profiling of Anti-SARS-CoV-2 Antibodies for Detecting Early Seroconversion in COVID-19 Patients
(2020-05-02)The COVID-19 pandemic continues to infect millions of people worldwide. In order to curb its spread and reduce morbidity and mortality, it is essential to develop sensitive and quantitative methods that identify infected ...