dc.contributor.author | Usman, Muhammad Shariq et al. | |
dc.date.accessioned | 2020-08-07T19:56:00Z | |
dc.date.available | 2020-08-07T19:56:00Z | |
dc.date.issued | 2020-06-02 | |
dc.identifier.uri | https://www.ajconline.org/article/S0002-9149(20)30548-8/fulltext | en_US |
dc.identifier.uri | https://www.epistemonikos.org/documents/6acef577c6a0963c7e71425950b1add0c0033d54 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/2109 | |
dc.description.abstract | The angiotensin converting enzyme (ACE) 2 is a cell surface protein used for entry into type II pneumocytes and other tissues by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the infective agent of COVID-19. It has been demonstrated that ACE2 is upregulated on tissues by renin-angiotensin-aldosterone system (RAAS) inhibitors. This raised concerns that RAAS inhibitors may increase susceptibility and worsen prognosis in COVID-19. In contrast, ACE2 facilitates degradation of angiotensin II and has an anti-inflammatory function and may actually protect the lungs and other tissues from injury. Thus, the effect of RAAS inhibitors on susceptibility and prognosis of COVID-19 continues to be the subject of much debate. Individual observational studies in the area have yielded equivocal results; hence, we sought to conduct a meta-analysis of all available data to provide greater insight... | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus Infections | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Renin-Angiotensin System | en_US |
dc.subject | Betacoronavirus | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.title | A Meta-analysis of the Relationship Between Renin-Angiotensin-Aldosterone System Inhibitors and COVID-19 | en_US |
eihealth.country | Others | en_US |
eihealth.category | Candidate therapeutics RD | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | American Journal of Cardiology | en_US |