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The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients
dc.contributor.author | Jing Yuan et. al. | |
dc.date.accessioned | 2020-04-01T00:59:55Z | |
dc.date.available | 2020-04-01T00:59:55Z | |
dc.date.issued | 2020-03-29 | |
dc.identifier.uri | https://doi.org/10.1007/s00011-020-01342-0 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/874 | |
dc.description.abstract | Objective:This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People’s Hospital, enrolled from Jan 5 to Feb 13, 2020. Methods: The clinical and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. Results: COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir + ribavirin. Conclusions: Therapeutic regimens of IFN-α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Lopinavir | en_US |
dc.subject | Ritonavir | en_US |
dc.subject | Lactate Dehydrogenase | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Infectious Diseases | en_US |
dc.title | The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients | en_US |
eihealth.country | Others | en_US |
eihealth.category | Clinical characterization and management | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | Inflammation Research | en_US |
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