High levels of PEEP are not better than low levels for reducing mortality in adult ICU patients with acute respiratory distress syndrome (ARDS) or acute lung injury (ALI)
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What is this? Some patients with COVID-19 will develop acute respiratory distress syndrome (ARDS) or acute lung injury (ALI) and need help with their breathing. This might be provided by mechanical ventilation (MV) in an intensive care unit (ICU). High levels of positive end-expiratory pressure (PEEP) might be used to prevent lung damage during MV. In this Cochrane systematic review, the authors searched for randomized trials to assess the effects of high versus low levels of PEEP in patients with ARDS or ALI. They did not restrict by language of publication and did their searches in May 2013. They identified 7 randomized trials (2565 participants).