dc.contributor.author | Yang CW et al. Department of Microbiology, Soochow University | |
dc.date.accessioned | 2020-03-18T16:32:01Z | |
dc.date.available | 2020-03-18T16:32:01Z | |
dc.date.issued | 2020-03-10 | |
dc.identifier.uri | https://doi.org/10.1016/j.jmii.2020.03.002 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/451 | |
dc.description.abstract | Translation of a genetic codon without a cognate tRNA gene is affected by both the cognate tRNA availability and the interaction with non-cognate isoacceptor tRNAs. Moreover, two consecutive slow codons (slow di-codons) lead to a much slower translation rate. Calculating the composition of host specific slow codons and slow di-codons in the viral protein coding sequences can predict the order of viral protein synthesis rates between different virus strains. Comparison of human-specific slow codon and slow di-codon compositions in the genomes of 590 coronaviruses infect humans revealed that the protein synthetic rates of 2019 novel coronavirus (2019-nCoV) and severe acute respiratory syndrome-related coronavirus (SARS-CoV) may be much faster than other coronaviruses infect humans. Analysis of host-specific slow codon and di-codon compositions provides links between viral genomic sequences and capability of virus replication in host cells that may be useful for surveillance of the transmission potential of novel viruses. | en_US |
dc.title | Composition of human-specific slow codons and slow di-codons in SARS-CoV and 2019-nCoV are lower than other coronaviruses suggesting a faster protein synthesis rate of SARS-CoV and 2019-nCoV | en_US |
eihealth.country | Others | en_US |
eihealth.category | Virus: natural history, transmission and diagnostics | en_US |
eihealth.type | Research protocol information | en_US |