Browsing Technical documents and research evidence on COVID-19 by Title
Now showing items 1313-1332 of 1749
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Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial
(2020-04-29)Background: No specific antiviral drug has been proven effective for treatment of patients with severe coronavirus disease 2019 (COVID-19). Remdesivir (GS-5734), a nucleoside analogue prodrug, has inhibitory effects on ... -
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
(2020-04-13)Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Replication of SARS-CoV-2 depends ... -
Remdesivir: A potential game-changer or just a myth? A systematic review and meta-analysis
(2020-10-26)Aims: COVID-19 outbreak has created a public health catastrophe all over the world. Here, we have aimed to conduct a systematic review and meta-analysis on remdesivir use for COVID-19. Main methods: We searched Pubmed, ... -
Remote Delivery of MHPSS (Mental Health and Psychosocial) Interventions
(2020-09-08)The global COVID-19 pandemic has forced very different types of interventions to explore options for providing remote (digital, tele, or online) Mental Health and Psychosocial Support (MHPSS), mainly due to the public ... -
Renal changes and acute kidney injury in covid-19: a systematic review
(2020-09-21)OBJECTIVE: We aimed to present a review of renal changes in patients with COVID-19. METHODS: We performed a systematic review of the literature to identify original articles regarding clinical, laboratory, and anatomopathological ... -
Renin–angiotensin–aldosterone system inhibitors and the risk of mortality in patients with hypertension hospitalised for COVID-19: systematic review and meta-analysis
(2020-11-05)Objective: The association between the use of renin–angiotensin–aldosterone (RAAS) inhibitors and the risk of mortality from COVID-19 is unclear. We aimed to estimate the association of RAAS inhibitors, including ACE ... -
Repeated population-based surveys of antibodies against SARS-CoV-2 in Southern Brazil
(2020-05-10)Population based data on COVID-19 are urgently needed for informing policy decisions, yet few such studies are available anywhere, as most surveys rely on self-selected volunteers. In the Brazilian State of Rio Grande do ... -
Report on the Epidemiological Features of Coronavirus Disease 2019 (COVID-19) Outbreak in the Republic of Korea from January 19 to March 2, 2020
(2020-03-16)Since the first case of coronavirus disease19 (COVID-19) was reported in Wuhan, China, as of March 2, 2020, the total number of confirmed cases of COVID-19 was 89,069 cases in 67 countries and regions. As of 0 am, March ... -
A report on the outbreak of Zika virus on Easter Island, South Pacific, 2014
(2016)Zika virus (ZIKV) is an emerging mosquito-borne flavivirus circulating in Asia and Africa. In 2013, a large outbreak was reported on the archipelago of French Polynesia. In this study, we report the detection and molecular ... -
Reported quality of life in countries with cases of COVID19: a systematic review
(2020-10-15)Introduction: Considering the relevance of the quality of life (QoL) and the consequences of the 2019 new coronavirus disease (COVID-19) due to the social distancing, this systematic review aimed to summarize effects of ... -
Repositioned chloroquine and hydroxychloroquine as antiviral prophylaxis for COVID-19: A protocol for rapid systematic review of randomized controlled trials
(2020-04-23)Since the SARS-CoV-2 outbreak rapidly evolved into a pandemic, there is an urgent need for rapid development, identification and confirmation of efficacious antiviral prophylaxis. In this setting, the existing drugs ... -
Repurposing and reshaping of hospitals during the COVID-19 outbreak in South Korea
(2020-05-05)During the extensive outbreak of coronavirus disease 2019 (COVID-19) in South Korea, many strategies in the hospital setting, such as stratified patient care, the assignment of hospitals/beds by a task force team, and the ... -
Repurposing Immunomodulatory Therapies against Coronavirus Disease 2019 (COVID-19) in the Era of Cardiac Vigilance: A Systematic Review
(2020-07-23)The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in efforts to identify therapies to ameliorate adverse clinical outcomes. The recognition of the key role for increased inflammation in COVID-19 has led ... -
Repurposing Therapeutics for Potential Treatment of SARS-CoV-2: A Review
(2020-06-30)The need for proven disease-specific treatments for the novel pandemic coronavirus SARS-CoV-2 necessitates a worldwide search for therapeutic options. Since the SARS-CoV-2 virus shares extensive homology with SARS-CoV and ... -
Requirements and technical specifications of personal protective equipment (PPE) for the novel coronavirus (2019-ncov) in healthcare settings. Interim recommendations, 2/6/2020
(2020-02-06)In December 2019 a novel coronavirus (2019-nCoV) was identified as the causative agent of a severe acute respiratory illness among people exposed in a seafood market in Wuhan, China; • Human-to-human transmission has been ... -
Requirements and technical specifications of personal protective. Interim recommendations, 2 February 2020
(2020-02-02)respiratory illness among people exposed in a seafood market in Wuhan, China; • Human-to-human transmission has been documented, including in healthcare workers, and aerosol-generating procedures (AGP)† may play a role in ... -
Research Progress of Chloroquine and Hydroxychloroquine on the COVID-19 and Their Potential Risks in Clinic Use
(2020-07-31)In December 2019, a severe outbreak of a novel coronavirus (COVID-19) occurred in the whole world, posing a great threat to people’s health. With the outbreak and development of the epidemic, how to improve the cure rate, ... -
Resilience in the time of pandemic: The experience of community pharmacists during COVID-19
(2020-05-20)Background: As a result of the COVID-19 pandemic, there has been a significant disruption of the practice of pharmacy. Importantly, in many parts of the world, this disruption occurred literally overnight, requiring ...