Show simple item record

dc.contributor.authorDos Santos, T
dc.contributor.authorRodriguez, A
dc.contributor.authorAlmiron, M
dc.contributor.authoret al.
dc.description.abstractZika virus (ZIKV) disease had been described as a mild, self-limiting illness associated with fever, rash, joint pain, and conjunctivitis.1 However, during the outbreak in French Polynesia, 42 patients with ZIKV disease were found to have the Guillain–Barré syndrome, which represented a marked increase from the approximately 5 cases detected annually during the previous 4 years.2 A connection with the Guillain–Barré syndrome had previously been described in association with other flavivirus illnesses3,4 but not with ZIKV infection. From April 1, 2015, to March 31, 2016, a total of 164,237 confirmed and suspected cases of ZIKV disease and 1474 cases of the Guillain–Barré syndrome were reported in Bahia, Brazil; Colombia; the Dominican Republic; El Salvador; Honduras; Suriname; and Venezuela. To examine the temporal association between ZIKV disease and the Guillain–Barré syndrome, graphical and time-series analyses were applied to these two independent data sets, which were collected through official International Health Regulations channels or from ministry of health websites (see the Supplementary Appendix, available with the full text of this letter at The data obtained from country reports contained no personally identifiable information and were collected as part of routine public health surveillance; therefore, the analysis was exempt from review by an ethics board. Differences between the observed and expected numbers of cases of the Guillain–Barré syndrome during the ZIKV transmission period, as well as differences in the incidence of the Guillain–Barré syndrome and ZIKV disease according to age and sex, were analyzed with the use of Poisson regression models (see the Supplementary Appendix).en_US
dc.subjectZika Research Projecten_US
dc.subjectZika Virusen_US
dc.subjectGuillain-Barre Syndromeen_US
dc.titleZika Virus and the Guillain-Barre Syndrome - Case Series from Seven Countriesen_US
eihealth.categoryEpidemiology and epidemiological studiesen_US
eihealth.typeResearch protocol informationen_US
eihealth.maincategorySave Lives / Salvar Vidasen_US
dc.relation.ispartofjournalThe New England Journal of Medicineen_US

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record