Intrauterine Zika virus infection and microcephaly: perinatal imaging correlations with 3D virtual physical models
Abstract
Zika virus (ZIKV) belongs to the same family of flaviviruses as dengue (DENV) and chikungunya (CHIKV) and, the Ae. aegypti and Ae. albopictus mosquitoes are recognized as transmitting agents. Zika virus was first identified in Uganda in 1947 and few cases were reported in humans until 2007 when a ZIKV outbreak occurred in Yap, Micronesia1. The first autochthonous transmission of ZIKV infection was reported in Brazil in June 20152 and ZIKV has now reached the Americas, most likely as a result of travel to and from the 2014 FIFA World Cup in Brazil3.
In adults, ZIKV infection causes cutaneous rash, fever, general illness and symptoms overlapping those of Guillain–Barré syndrome4.