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dc.contributor.authorTang, Hengli
dc.contributor.authorHammack, Christy
dc.contributor.authorOgden, Sarah C
dc.contributor.authoret al.
dc.date.accessioned2022-09-05T20:10:45Z
dc.date.available2022-09-05T20:10:45Z
dc.date.issued2016-06
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/26952870/en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12663/2976
dc.description.abstractThe suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and microcephaly is an urgent global health concern. The direct target cells of ZIKV in the developing human fetus are not clear. Here we show that a strain of the ZIKV, MR766, serially passaged in monkey and mosquito cells efficiently infects human neural progenitor cells (hNPCs) derived from induced pluripotent stem cells. Infected hNPCs further release infectious ZIKV particles. Importantly, ZIKV infection increases cell death and dysregulates cell-cycle progression, resulting in attenuated hNPC growth. Global gene expression analysis of infected hNPCs reveals transcriptional dysregulation, notably of cell-cycle-related pathways. Our results identify hNPCs as a direct ZIKV target. In addition, we establish a tractable experimental model system to investigate the impact and mechanism of ZIKV on human brain development and provide a platform to screen therapeutic compounds.en_US
dc.languageEnglishen_US
dc.subjectZika Research Projecten_US
dc.subjectZika Virusen_US
dc.subjectZika Virus Infectionen_US
dc.titleZika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growthen_US
eihealth.countryOthersen_US
eihealth.categoryEpidemiology and epidemiological studiesen_US
eihealth.typeResearch protocol informationen_US
eihealth.maincategorySave Lives / Salvar Vidasen_US
dc.relation.ispartofjournalCell Stem Cellen_US
dc.contributor.corporatenameUnited States of America. Florida State Universityen_US
dc.contributor.corporatenameUnited States of America. Johns Hopkins University School of Medicineen_US


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