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dc.contributor.authorLi, Cui. et al.
dc.date.accessioned2022-03-15T03:14:45Z
dc.date.available2022-03-15T03:14:45Z
dc.date.issued2016-05
dc.identifier.urihttps://www.cell.com/cell-stem-cell/fulltext/S1934-5909(16)30084-4#%20en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12663/2689
dc.description.abstractThe link between Zika virus (ZIKV) infection and microcephaly has raised urgent global alarm. The historical African ZIKV MR766 was recently shown to infect cultured human neural precursor cells (NPCs), but unlike the contemporary ZIKV strains, it is not believed to cause microcephaly. Here we investigated whether the Asian ZIKV strain SZ01 could infect NPCs in vivo and affect brain development. We found that SZ01 replicates efficiently in embryonic mouse brain by directly targeting different neuronal linages. ZIKV infection leads to cell-cycle arrest, apoptosis, and inhibition of NPC differentiation, resulting in cortical thinning and microcephaly. Global gene expression analysis of infected brains reveals upregulation of candidate flavirus entry receptors and dysregulation of genes associated with immune response, apoptosis, and microcephaly. Our model provides evidence for a direct link between Zika virus infection and microcephaly, with potential for further exploration of the underlying mechanisms and management of ZIKV-related pathological effects during brain development.en_US
dc.languageEnglishen_US
dc.subjectZika Research Projecten_US
dc.subjectZika Virus Infectionen_US
dc.subjectMicrocephalyen_US
dc.subjectBrazilen_US
dc.subjectAmericasen_US
dc.titleZika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Miceen_US
eihealth.countryOthersen_US
eihealth.categoryEpidemiology and epidemiological studiesen_US
eihealth.typePublished Articleen_US
eihealth.maincategoryProtect Health Care Workers / Proteger la Salud de los Trabajadoresen_US
dc.relation.ispartofjournalCell Stem Cellen_US


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