dc.contributor.author | Lukito, Antonia Anna et al. | |
dc.date.accessioned | 2021-04-01T14:43:46Z | |
dc.date.available | 2021-04-01T14:43:46Z | |
dc.date.issued | 2020-11-11 | |
dc.identifier.uri | https://doi.org/10.1016/j.dsx.2020.11.006 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/2563 | |
dc.description.abstract | Background and aims: Diabetes is one of the most common comorbidities, and it is associated with poorer outcomes in patients with coronavirus disease 2019 (COVID-19). Preliminary findings showed that mortality was reduced in those who consume metformin compared to those who did not, and given its low cost and widespread availability; metformin is an attractive and potential agent to mitigate excessive risk in diabetic populations. Methods: Several medical databases (Pubmed, EuropePMC, EBSCOhost, Proquest, Cochrane library) and two health-science preprint servers (preprint.org and Medrxiv) were systematically searched for relevant literature. Results: Nine studies with 10,233 subjects were included in the qualitative and quantitative synthesis. Meta-analysis showed that metformin is associated with lower mortality in pooled non-adjusted model (OR 0.45 [0.25, 0.81], p = 0.008; I2: 63.9%, p = 0.026) and pooled adjusted model (OR 0.64 [0.43, 0.97], p = 0.035; I2: 52.1%, p = 0.064). Conclusion: The analysis showed that metformin consumption was associated with lower mortality. Randomized controlled trials are needed to confirm this finding. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus Infections | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Betacoronavirus | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | Diabetes Mellitus | en_US |
dc.subject | Metformin | en_US |
dc.subject | Mortality | en_US |
dc.title | The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis | en_US |
eihealth.country | Others | en_US |
eihealth.category | Clinical characterization and management | en_US |
eihealth.category | Candidate therapeutics RD | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | Diabetes & Metabolic Syndrome: Clinical Research & Reviews | en_US |