dc.contributor.author | Elhabyan, Abdelazeem et al. | |
dc.date.accessioned | 2021-03-15T17:53:04Z | |
dc.date.available | 2021-03-15T17:53:04Z | |
dc.date.issued | 2020-11 | |
dc.identifier.uri | https://doi.org/10.1016/j.virusres.2020.198163 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/2517 | |
dc.description.abstract | Background: Susceptibility to severe viral infections was reported to be associated with genetic variants in immune response genes using case reports and GWAS studies. SARS-CoV-2 is an emergent viral disease that caused millions of COVID-19 cases all over the world. Around 15 % of cases are severe and some of them are accompanied by dysregulated immune system and cytokine storm. There is increasing evidence that severe manifestations of COVID-19 might be attributed to human genetic variants in genes related to immune deficiency and or inflammasome activation (cytokine storm).
Objective: Identify the candidate genes that are likely to aid in explaining severe COVID-19 and provide insights to understand the pathogenesis of severe COVID-19.
Methods: In this article, we systematically reviewed genes related to viral susceptibility that were reported in human genetic studies (Case-reports and GWAS) to understand the role of host viral interactions and to provide insights into the pathogenesis of severe COVID-19.
Results: We found 40 genes associated with viral susceptibility and 21 of them were associated with severe SARS-CoV disease and severe COVID-19. Some of those genes were implicated in TLR pathways, others in C-lectin pathways, and others were related to inflammasome activation (cytokine storm).
Conclusion: This compilation represents a list of candidate genes that are likely to aid in explaining severe COVID-19 which are worthy of inclusion in gene panels and during meta-analysis of different variants in host genetics studies of COVID-19. In addition, we provide several hypotheses for severe COVID-19 and possible therapeutic targets. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus Infections | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Cytokine Release Syndrome | en_US |
dc.subject | Inflammasomes | en_US |
dc.subject | Interferons | en_US |
dc.subject | Interleukins | en_US |
dc.subject | SARS Virus | en_US |
dc.subject | Systematic Review | en_US |
dc.title | The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: A systematic review | en_US |
eihealth.country | Others | en_US |
eihealth.category | Virus: natural history, transmission and diagnostics | en_US |
eihealth.category | Epidemiology and epidemiological studies | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Slow Spread / Reducir la Dispersión | en_US |
dc.relation.ispartofjournal | Virus Res | en_US |