| dc.contributor.author | Chen, Guang et al. | |
| dc.date.accessioned | 2020-12-30T20:38:25Z | |
| dc.date.available | 2020-12-30T20:38:25Z | |
| dc.date.issued | 2020-03-27 | |
| dc.identifier.uri | https://doi.org/10.1172/JCI137647 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12663/2452 | |
| dc.description.abstract | The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design. | en_US |
| dc.language | English | en_US |
| dc.subject | COVID-19 | en_US |
| dc.subject | Coronavirus | en_US |
| dc.subject | Coronavirus Infections | en_US |
| dc.subject | Infectious Diseases | en_US |
| dc.subject | Clinical Medicine | en_US |
| dc.subject | Allergy and Immunology | en_US |
| dc.title | SARS-CoV-2: a storm is raging | en_US |
| eihealth.country | Others | en_US |
| eihealth.category | Clinical characterization and management | en_US |
| eihealth.type | Published Article | en_US |
| eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
| dc.relation.ispartofjournal | Journal of Clinical Investigation | en_US |
