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dc.contributor.authorBennett, Sadie et al.
dc.date.accessioned2020-10-07T20:31:10Z
dc.date.available2020-10-07T20:31:10Z
dc.date.issued2020-09-23
dc.identifier.urihttps://doi.org/10.1111/ijcp.13725en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12663/2326
dc.description.abstractBackground: The 2019 coronavirus disease (COVID‐19) has become a global pandemic and the published literature describing the virus has grown exponentially. Methods: We conducted a systematic review of the literature to identify the symptoms, comorbidities present, radiological features and outcomes for adults testing positive for COVID‐19 admitted to hospital. The results across multiple studies were numerically pooled to yield total estimated. Results: A total of 45 studies were included in this review with 14,358 adult participants (average age 51 years, male 51%). The pooled findings suggest that the most common symptom among patients was fever (81.2%) followed by cough (62.9%), fatigue (38.0%) and anorexia/loss of appetite (33.7%). The comorbidities that were most prevalent among patients with the virus were hypertension (19.1%), cardiovascular disease (17.9%), endocrine disorder (9.3%) and diabetes (9.2%). Abnormal chest X‐ray findings were present in 27.7% of patients and ground‐glass opacity was demonstrated on chest CT in 63.0% of patients. The most frequent adverse outcomes were acute respiratory distress syndrome (27.4%), acute cardiac injury (16.2%) and acute kidney injury (12.6%). Death occurred in 8.2% of patients and 16.3% required intensive care admission and 11.7% had mechanical ventilation. Bacterial or secondary infections affected 8.5% of patients and 6.9% developed shock. Conclusions: COVID‐19 most commonly presents with fever, cough, fatigue and anorexia among patients with existing hypertension and cardiovascular disease. It is important as serious adverse outcomes can develop such as acute respiratory distress syndrome, acute cardiac injury, acute kidney injury and death.en_US
dc.languageEnglishen_US
dc.subjectCOVID-19en_US
dc.subjectCoronavirus Infectionsen_US
dc.subjectCoronavirusen_US
dc.subjectInfectious Diseasesen_US
dc.subjectSystematic Reviewen_US
dc.titleClinical features and outcomes of adults with COVID‐19: A systematic review and pooled analysis of the literatureen_US
eihealth.countryOthersen_US
eihealth.categoryClinical characterization and managementen_US
eihealth.typePublished Articleen_US
eihealth.maincategoryProtect Health Care Workers / Proteger la Salud de los Trabajadoresen_US
dc.relation.ispartofjournalThe International Journal of Clinical Practiceen_US


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