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dc.contributor.authorGupta, Aakriti et al.
dc.date.accessioned2020-08-07T18:22:16Z
dc.date.available2020-08-07T18:22:16Z
dc.date.issued2020-07-10
dc.identifier.urihttps://doi.org/10.1038/s41591-020-0968-3en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12663/2107
dc.description.abstractAlthough COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. In addition, endothelial damage and thromboinflammation, dysregulation of immune responses, and maladaptation of ACE2-related pathways might all contribute to these extrapulmonary manifestations of COVID-19. Here we review the extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19 to aid clinicians and scientists in recognizing and monitoring the spectrum of manifestations, and in developing research priorities and therapeutic strategies for all organ systems involved.en_US
dc.languageEnglishen_US
dc.subjectCOVID-19en_US
dc.subjectCoronavirus Infectionsen_US
dc.subjectInfectious Diseasesen_US
dc.subjectSARS-CoV-2en_US
dc.titleExtrapulmonary manifestations of COVID-19en_US
eihealth.countryOthersen_US
eihealth.categoryInfection prevention and control, including health care workers protectionen_US
eihealth.categoryOperation readiness, surge capacityen_US
eihealth.categoryPrehospital Emergency Medical Servicesen_US
eihealth.typePublished Articleen_US
eihealth.maincategorySave Lives / Salvar Vidasen_US
dc.relation.ispartofjournalNature Medicineen_US


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