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Pregnancy and breastfeeding during COVID-19 pandemic: A systematic review of published pregnancy cases
(2020-05-05)Background: The COVID-19 pandemic is an emerging concern regarding the potential adverse effects during pregnancy. This study reviews knowledge on the impact of COVID-19 on pregnancy and describes the outcome of published ... -
The role of asymptomatic SARS-CoV-2 infections: rapid living systematic review and meta-analysis
(2020-05-24)OBJECTIVE To address three questions: 1. amongst people who become infected with SARS-CoV-2, what proportion does not experience symptoms at all during their infection? 2. Amongst people with SARS-CoV-2 infection who are ... -
Low blood sodium increases risk and severity of COVID-19: a systematic review, meta-analysis and retrospective cohort study
(2020-05-22)Background Novel coronavirus (SARS-CoV-2) infects human lung tissue cells through angiotensin-converting enzyme-2 (ACE2), and the body sodium is an important factor for regulating the expression of ACE2. Through a systematic ... -
Evidence-Based, Cost-Effective Interventions To Suppress The COVID-19 Pandemic: A Systematic Review
(2020-06-15)Background: In an unparalleled global response, during the COVID-19 pandemic, 90 countries asked 3.9 billion people to stay home. Yet some countries avoided lockdowns and focused on other strategies, like contact tracing ... -
Hydroxychloroquine safety: A meta-analysis of randomized controlled trials
(2020-07-06)Background: Hydroxychloroquine (HCQ) is currently being examined for COVID-19. No previous meta-analysis has evaluated its side effects versus placebo. We conducted this meta-analysis to compare the safety of HCQ versus ... -
Safety and Efficacy of Hydroxychloroquine in COVID-19: A Systematic Review and Meta-Analysis
(2020-08)Background: During the initial phases of the coronavirus disease 2019 (COVID-19) epidemic, there was an unfounded fervor surrounding the use of hydroxychloroquine (HCQ); however, recently, the Centers for Disease Control ... -
Exploring Repurposing Potential of Existing Drugs in the Management of COVID-19 Epidemic: A Critical Review
(2020-08)Despite high morbidity and mortality of ongoing coronavirus disease 2019 (COVID-19) pandemic, no specific therapy has been established till date. Though in vitro studies identified various molecules as possible therapies ... -
Directly Acting Antivirals for COVID-19: Where Do We Stand?
(2020-08-05)The outbreak of a novel coronavirus (SARS-CoV-2) in Wuhan, China in December 2019 has now become a pandemic with no approved therapeutic agent. At the moment, the genomic structure, characteristics, and pathogenic mechanisms ... -
Possible Retinal Impairment Secondary to Ritonavir Use in SARS-CoV-2 Patients: A Narrative Systematic Review
(2020-08)Some reports described a possible ritonavir-related retinal toxicity. The objective of this research was to review and analyze previous studies conducted on ritonavir administration and retinal impairment in a narrative ... -
Corticosteroid therapy for critically ill patients with COVID-19: A structured summary of a study protocol for a prospective meta-analysis of randomized trials
(2020-08-24)Primary objective: To estimate the effect of corticosteroids compared with usual care or placebo on mortality up to 28 days after randomization. Secondary objectives: To examine whether the effect of corticosteroids compared ...