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A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19
(2020-03-10)Purpose: COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting ... -
Pivotal Role of Convalescent Plasma in Managing Emerging Infectious Diseases
(2020-04-02)Infectious diseases remain one of the top 10 global health threats as announced by the World Health Organization. The emergence of new pathogens for which there is no effective treatment has redrawn the attention to the ... -
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
(2020-04-13)Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Replication of SARS-CoV-2 depends ... -
Lopinavir-ritonavir for COVID-19: A living systematic review
(2020-07-15)Objective: Provide a timely, rigorous, and continuously updated summary of the evidence on the role of lopinavir/ritonavir in the treatment of patients with COVID-19. Methods: We conducted searches in the special L·OVE ... -
Neurological associations of COVID-19
(2020-07-02)Background: The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is of a scale not seen since the 1918 influenza pandemic. Although the predominant clinical presentation is with ... -
Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019
(2020-05-14)Objective To assess the efficacy and safety of hydroxychloroquine plus standard of care compared with standard of care alone in adults with coronavirus disease 2019 (covid-19). Design Multicentre, open label, randomised ... -
Obesity a predictor of outcomes of COVID‐19 hospitalized patients‐ A systematic Review and Meta‐Analysis
(2020-09-25)Background: COVID‐19 pandemic is a global health crisis. Very few studies have reported association between obesity and severity of COVID‐19. In this meta‐analysis, we assessed the association of obesity and outcomes in ... -
Systematic Review and Meta-analysis of Smell and Taste Disorders in COVID-19
(2020-09-11)Objective: Loss of smell and taste are considered potential discriminatory symptoms indicating triaging for coronavirus disease 2019 (COVID-19) and early case identification. However, the estimated prevalence essential to ... -
Probiotics against viruses; COVID-19 is a paper tiger: A Systematic Review
(2020-09-17)Background: Probiotics can improve immune function for prevention and management of viral infections like SARS-CoV-2 infection (COVID-19 disease). Methods: We searched on PubMed, EMBASE, Google Scholar, Science Direct, ... -
Companion animals likely do not spread COVID-19 but may get infected themselves
(2020-08-07)Coronavirus disease 2019 (COVID-19) is a highly contagious infectious disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). From the epidemiological data, the picture emerges that the ...