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Hydroxychloroquine: a potential ethical dilemma for rheumatologists during the COVID-19 pandemic
(2020-04)Two antimalarial agents, chloroquine (CQ) and hydroxychloroquine (HCQ), have been trusted treatments for a range of rheumatic diseases over the past seventy years [1]. These agents have attracted intense media attention ... -
The ethics of COVID-19 treatment studies: too many are open, too few are double-masked
(2020-06-30)A WHO panel, convened during the 2014 Ebola virus epidemic, assessed the ethical implications of using medicines that have shown promising results in the laboratory and in animal models, but before they have been evaluated ... -
SARS-CoV-2 pandemic in Italy: ethical and organizational considerations
(2020-05-25)The current SARS-CoV-2 pandemic is still raging in Italy. The country is currently plagued by a huge burden of virus relatedcases and deaths. So far, the disease has highlighted a number of problems, some in common with ... -
Pregnancy and COVID-19
(2020-07-15)Citation: Della Gatta AN, Rizzo R, Pilu G, Simonazzi G. Coronavirus 19 during pregnancy: a systematic review of reported cases. American Journal of Obstetrics and Gynecology. 2020 Jul;223(1):36-41. What is this? Understanding ... -
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
(2020-06-17)BACKGROUND: There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide ... -
Interventions for people with disabilities in low‐and middle‐income countries: evidence and gap map
(2020-07-16)Citation: Saran A, White H, Kuper H. Evidence and gap map of studies assessing the effectiveness of interventions for people with disabilities in low‐and middle‐income countries. Campbell Systematic Reviews. 2020;16(1):e1070. ... -
Repurposing Therapeutics for Potential Treatment of SARS-CoV-2: A Review
(2020-06-30)The need for proven disease-specific treatments for the novel pandemic coronavirus SARS-CoV-2 necessitates a worldwide search for therapeutic options. Since the SARS-CoV-2 virus shares extensive homology with SARS-CoV and ... -
Characteristics of registered clinical trials assessing treatments for COVID-19: a cross-sectional analysis
(2020-06-09)Objectives The coronavirus disease 2019 (COVID-19) pandemic has prompted many initiatives to identify safe and efficacious treatments, yet little is known regarding where early efforts have focused. We aimed to characterise ... -
Retraction and republication: cardiac toxicity of hydroxychloroquine in COVID-19
(2020-07-09)A recent Lancet Article by Mandeep Mehra and colleagues, which reported adverse events associated with hydroxychloroquine or chloroquine treatment in patients with COVID-19, has been retracted by three of the authors, along ...