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Anti-hypertensive Angiotensin II receptor blockers associated to mitigation of disease severity in elderly COVID-19 patients
(2020-03-27)Background: The novel coronavirus (CoV) severe acute respiratory syndrome (SARS)-CoV-2 outbreak started at the end of 2019 in Wuhan, China, and spread over 100 countries. SARS-CoV-2 uses the membrane protein Angiotensin I ... -
Pivotal Role of Convalescent Plasma in Managing Emerging Infectious Diseases
(2020-04-02)Infectious diseases remain one of the top 10 global health threats as announced by the World Health Organization. The emergence of new pathogens for which there is no effective treatment has redrawn the attention to the ... -
Of Chloroquine and COVID-19
Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific ... -
Off-label use of medicines for COVID-19. Scientific brief, 31 March 2020
(2020-03-31)No pharmaceutical products have yet been shown to be safe and effective for the treatment of COVID-19. However, a number of medicines have been suggested as potential investigational therapies, many of which are now being ... -
Advice on the use of point-of-care immunodiagnostic tests for COVID-19. Scientific Brief, 8 April 2020
(2020-04-08)In response to the growing COVID-19 pandemic and shortages of laboratory-based molecular testing capacity and reagents, multiple diagnostic test manufacturers have developed and begun selling rapid and easy-to-use devices ... -
Assessment tool for laboratories implementing COVID-19 virus testing. Interim guidance, 8 April 2020
(2020-04-08)Background: This tool has been designed to assess the capacity of laboratories that have implemented or intend to implement testing for SARS-CoV-2, the virus that causes novel coronavirus disease 2019 (COVID-19). The tool ... -
Mesenchymal Stem Cell Therapy for COVID-19: Present or Future
(2020-04-13)“COVID-19” is the word that certainly isn’t forgotten by everybody who lives in the first half of the twenty-first century. COVID-19, as a pandemic, has led many researchers from different biomedical fields to find solutions ... -
N-acetylcysteine: A rapid review of the evidence for effectiveness in treating COVID-19
(2020-04-14)An old drug repurposed? N-acetylcysteine (NAC) was introduced in the 1960s as a mucolytic drug for chronic respiratory diseases. It has a well-established safety profile and is still commonly used orally at doses of 600mg/day ... -
Lopinavir/ritonavir: A rapid review of effectiveness in COVID-19
(2020-04-14)There are currently no pharmacological treatments for COVID-19. Due to the urgent need for effective treatments, there has been increased interest in re-purposing currently available drugs for immediate use. The antiretroviral ... -
Do stem cells have a role in the treatment of COVID-19?
(2020-04-13)Stem cells get their name from their ability to divide and then transform into any type of tissue. This means they can ‘procreate’ multiple cells of any type, something other cells cannot do. The treatment with stem cells ...