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A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19
(2020-03-10)Purpose: COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting ... -
Chloroquine and hydroxychloroquine: Current evidence for their effectiveness in treating COVID-19
(2020-03-25)Verdict: Several in vitro studies report antiviral activity of chloroquine and hydroxychloroquine against SARS-CoV-2. In vivo data, although promising, is currently limited to one study with considerable limitations. On ... -
Chapter of Gastroenterologists professional guidance on risk mitigation for gastrointestinal endoscopy during COVID-19 pandemic in Singapore
(2020-04-03)[Abstract]. In this paper, we aimed to provide professional guidance to practising gastrointestinal (GI) endoscopists for the safe conduct of GI endoscopy procedures during the current coronavirus disease 2019 (COVID-19) ... -
Nervous system involvement after infection with COVID-19 and other coronaviruses
(2020-03-30)Viral infections have detrimental impacts on neurological functions, and even to cause severe neurological damage. Very recently, coronaviruses (CoV), especially severe acute respiratory syndrome CoV 2 (SARS-CoV-2), exhibit ... -
Coronavirus Disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up
(2020-03-15)[Abstract]. Objective: To investigate the characteristics and prognostic factors in the elderly patients with COVID-19. Methods: Consecutive cases over 60 years old with COVID-19 in Renmin Hospital of Wuhan University from ... -
Pivotal Role of Convalescent Plasma in Managing Emerging Infectious Diseases
(2020-04-02)Infectious diseases remain one of the top 10 global health threats as announced by the World Health Organization. The emergence of new pathogens for which there is no effective treatment has redrawn the attention to the ... -
Coronavirus disease 2019 (COVID-19): a clinical update
(2020-04-02)[Abstract]. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. It caused a total of 80 868 confirmed cases and 3101 ... -
Computational inference of selection underlying the evolution of the novel coronavirus, SARS-CoV-2
(2020-04-01)The novel coronavirus (SARS-CoV-2) recently emerged in China is thought to have a bat origin, as its closest known relative (BatCoV RaTG13) was described in horseshoe bats. We analyzed the selective events that accompanied ... -
The Rapid Assessment and Early Warning Models for COVID-19
(2020-04-01)Human beings have experienced a serious public health event as the new pneumonia (COVID-19), caused by the severe acute respiratory syndrome coronavirus has killed more than 3000 people in China, most of them elderly or ... -
Primary care management of the coronavirus (COVID-19)
(2020-03-31)South Africa is in the grip of a novel coronavirus pandemic (COVID-19). Primary care providers are in the frontline. COVID-19 is spread primarily by respiratory droplets contaminating surfaces and hands that then transmit ...