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High levels of PEEP are not better than low levels for reducing mortality in adult ICU patients with acute respiratory distress syndrome (ARDS) or acute lung injury (ALI)
(2020-03-18)What is this? Some patients with COVID-19 will develop acute respiratory distress syndrome (ARDS) or acute lung injury (ALI) and need help with their breathing. This might be provided by mechanical ventilation (MV) in an ... -
Noninvasive positive-pressure ventilation may help wean patients off mechanical ventilation
(2020-03-20)What is this? Some patients with COVID-19 will develop respiratory failure and need help with their breathing. This might be provided by mechanical ventilation (MV) in an intensive care unit (ICU), but this can cause ... -
Forecasting COVID-19 impact on hospital bed-days, ICU-days, ventilatordays and deaths by US state in the next 4 months
(2020-03-26)Key Points Question: Assuming social distancing measures are maintained, what are the forecasted gaps in available health service resources and number of deaths from the COVID-19 pandemic for each state in the United States? ... -
Decreased mortality associated with respiratory viral infections 3 between December 2019 and March 2020 compared to previous year, Southeast France
(2020-03)We observed 39% less deaths associated with common respiratory viruses during colder months of 2019-2020 compared to 2018-2019. Excess mortality associated with influenza virus infections is estimated to be 5.9 per 100,000 ... -
Estimates of the severity of coronavirus disease 2019: a model-based analysis
(2020-03-30)Background: In the face of rapidly changing data, a range of case fatality ratio estimates for coronavirus disease 2019 (COVID-19) have been produced that differ substantially in magnitude. We aimed to provide robust ... -
Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis
(2020-04-10)In the fight against coronavirus disease 2019 (COVID-19), now a worldwide pandemic, urgent identification of clinical and laboratory predictors of progression towards severe and fatal forms is urgently needed. These ... -
Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China
(2020-03-19)As of 29 February 2020 there were 79,394 confirmed cases and 2,838 deaths from COVID-19 in mainland China. Of these, 48,557 cases and 2,169 deaths occurred in the epicenter, Wuhan. A key public health priority during the ... -
Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study
(2020-04-03)Background: The global death toll from COVID-19 virus exceeds 21000. The risk factors for death were attributed to advanced age and co-morbidities, but haven't been accurately defined. Objectives: To report the clinical ... -
A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology
(2020-04-14)Using Richardson and Davidson’s model and the sciences of pharmacokinetics and clinical pharmacopsychology, this article reviewed the: (1) poor life expectancy associated with treatment-resistant schizophrenia (TRS), which ... -
Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan
(2020)Background: In December 2019, the coronavirus disease 2019 (COVID-19) outbreak occurred in Wuhan. Data on the clinical characteristics and outcomes of patients with severe COVID-19 are limited. Objective: We sought to ...