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A Multi-centre, Adaptive, Randomized, Double-Blind, PlaceboControlled Clinical Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Patients
This is a multi-centre, adaptive, randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of investigational therapeutic agents in combination with standard-of care for the treatment ... -
Clinical Practice Guideline of Acute Respiratory Distress Syndrome
(2016-08-16)There is no well-stated practical guideline for mechanically ventilated patients with or without acute respiratory distress syndrome (ARDS). We generate strong (1) and weak (2) grade of recommendations based on high (A), ... -
Colloids and crystalloids may have similar effects on mortality when used for fluid replacement in critically ill patients
(2020-03-16)What is this? Some patients with COVID-19 will become critically ill and may need additional fluids to prevent kidney failure. Fluid replacement options include colloids or crystalloids. Colloids are cheap and easy to use ... -
An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes
(2020-03)The emergence of a novel coronavirus, termed SARS-CoV-2, and the potentially life-threating respiratory disease that it can produce, COVID-19, has rapidly spread across the globe creating a massive public health problem. ... -
Composition of human-specific slow codons and slow di-codons in SARS-CoV and 2019-nCoV are lower than other coronaviruses suggesting a faster protein synthesis rate of SARS-CoV and 2019-nCoV
(2020-03-10)Translation of a genetic codon without a cognate tRNA gene is affected by both the cognate tRNA availability and the interaction with non-cognate isoacceptor tRNAs. Moreover, two consecutive slow codons (slow di-codons) ... -
Successful containment of COVID-19: the WHO-Report on the COVID-19 outbreak in China
(2020-03-17)SARS-CoV-2 is a new Coronavirus, with first infections detected in humans late in 2019. The emergence of SARS-CoV-2 has led to a large outbreak in China and is currently causing outbreaks in many countries. The disease ...