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Discovering Drugs to Treat Coronavirus Disease 2019 (COVID-19)
The SARS-CoV-2 virus emerged in December 2019 and then spread rapidly worldwide, particularly to China, Japan, and South Korea. Scientists are endeavoring to find antivirals specific to the virus. Several drugs such as ... -
Disposable Isolation Device to Reduce COVID-19 Contamination During CT Scanning
(2020-05-18)Rationale and Objectives: The use of chest computed tomography (CT) in the era of the COVID-19 pandemic raises concern regarding the transmission risks to patients and staff caused by CT room contamination. Meanwhile the ... -
The disproportionate rise in COVID-19 cases among Hispanic/Latinx in disadvantaged communities of Orange County, California: A socioeconomic case-series
(2020-05-07)Background: Recent epidemiological evidence has demonstrated a higher rate of COVID-19 hospitalizations and deaths among minorities. This pattern of race-ethnic disparities emerging throughout the United States raises the ... -
Disruptions during a pandemic: Gaps identified and lessons learned
(2020-06-04)Global disruptions caused by coronavirus disease 2019 (COVID‐19) affects all walks of life, and dentistry and dental education are no exceptions. Dental education uniquely blends didactic courses and hands‐on clinical ... -
Do COVID-19 patients admitted to the ICU require anti-Pneumocystis jirovecii prophylaxis?
(2020-05-22)We are currently facing a frightening increase in COVID-19 patients admitted to the ICU. Aiming at screening for secondary pneumonia, we collected the data of our first twelve ICU patients who underwent bronchoalveolar ... -
Do stem cells have a role in the treatment of COVID-19?
(2020-04-13)Stem cells get their name from their ability to divide and then transform into any type of tissue. This means they can ‘procreate’ multiple cells of any type, something other cells cannot do. The treatment with stem cells ... -
Does Asthma Increase the Mortality of Patients with COVID-19?: A Systematic Review and Meta-Analysis
(2020-09-22)The purpose of this systematic review and meta-analysis was to explore the literature and collate data comparing the mortality of coronavirus disease 2019 (COVID-19) patients with and without asthma. The databases PubMed, ... -
Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis
(2020-04-08)Currently, the number of patients with coronavirus disease 2019 (COVID-19) has increased rapidly, but relationship between comorbidity and patients with COVID-19 still not clear. The aim was to explore whether the presence ... -
Does gender influence clinical expression and disease outcomes in COVID-19? A systematic review and meta-analysis
(2020-08-12)Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) was characterized at the end of 2019, and soon spread around the world, generating a pandemic. It has been suggested that men are more severely affected ... -
Does TB Vaccination Reduce COVID-19 Infection?: No Evidence from a Regression Discontinuity Analysis
(2020-04-22)In the middle of the global COVID-19 pandemic, the BCG hypothesis, the prevalence and severity of the COVID-19 outbreak seems to be correlated with whether a country has a universal coverage of Bacillus-Calmette-Guerin ... -
Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis
(2020-05-06)Background: Severe acute respiratory syndrome coronavirus 2 (SARS−CoV−2) has been declared a global pandemic by the World Health Organisation and urgent treatment and prevention strategies are needed. Many clinical trials ... -
Doxycycline and Hydroxychloroquine as Treatment for High-Risk COVID-19 Patients: Experience from Case Series of 54 Patients in Long-Term Care Facilities
(2020-05-22)Importance: Patients in long-term care facilities (LTCF) are at a high-risk of contracting COVID-19 due to advanced age and multiple comorbidities. Without effective treatments, outbreaks in such facilities will become ... -
Drawing on Israel’s Experience Organizing Volunteers to Operationalize Drive-Through Coronavirus Testing Centers
(2020-04-16)To increase the country’s capacity to test and track suspected coronavirus disease 2019 (COVID-19) cases, Israel launched drive-through testing centers in key cities, including Tel Aviv, Jerusalem, Be’er Sheva, and Haifa. ... -
Drug treatments affecting ACE2 in COVID-19 infection: a systematic review protocol
(2020-07-14)Background: The SARS-CoV-2 virus causing COVID-19 binds human angiotensin-converting enzyme 2 (ACE2) receptors in human tissues. ACE2 expression may be associated with COVID-19 infection and mortality rates. Routinely ... -
Drug vignettes: Azithromycin
(2020-05-13)Description of the drug, including regulatory status: Azithromycin is a macrolide antibacterial drug, derived from erythromycin, licensed in the USA and in the UK, and used to treat bacterial infections. It has been used ... -
Drugs for treating acute respiratory distress syndrome (ARDS) in critically ill patients
(2020-03-16)What is this? Some patients with COVID-19 will develop acute respiratory distress syndrome (ARDS) and need help with their breathing. ARDS is caused by direct or indirect injury to the lungs and about 40% of people with ... -
The Dynamic Changes of Antibodies against SARS-CoV-2 during the Infection and Recovery of COVID-19
(2020-05-21)Deciphering the dynamic changes of antibodies against SARS-CoV-2 is essential for understanding the immune response in COVID-19 patients. By comprehensively analyzing the laboratory findings of 1,850 patients, we describe ... -
Dysregulation of immune response in patients with COVID-19 in Wuhan, China
(2020-03-12)[Conclusions] Of the 452 patients with COVID-19 recruited, 286 were diagnosed as severe infection. The median age was 58 years and 235 were male. The most common symptoms were fever, shortness of breath, expectoration, ...