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dc.contributor.authorChang, Raymond
dc.contributor.authorSun, Wei-Zen
dc.date.accessioned2020-06-29T14:51:02Z
dc.date.available2020-06-29T14:51:02Z
dc.date.issued2020-04-23
dc.identifier.urihttps://doi.org/10.1101/2020.04.18.20071167en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12663/1839
dc.description.abstractSince the SARS-CoV-2 outbreak rapidly evolved into a pandemic, there is an urgent need for rapid development, identification and confirmation of efficacious antiviral prophylaxis. In this setting, the existing drugs chloroquine (CQ) and hydroxychloroquine (HCQ) which has suggestive evidence of efficacy against SARS-CoV-2 infection and COVID-19 disease has become prime candidates to be repositioned as therapeutic and preventative agents, and a growing number of clinical trials have been registered to study their preventative potential for at-risk populations using a range of dosing schemes and outcome measures. This rapid systematic review protocol aims to provide streamlined and timely synthesis on methodologies and results of randomized controlled trials assessing the efficacy of CQ and HCQ in hopes that this will constructively inform further research as well as public health policy.en_US
dc.languageEnglishen_US
dc.subjectCOVID-19en_US
dc.subjectCoronavirusen_US
dc.subjectHydroxychloroquineen_US
dc.subjectDrug Therapyen_US
dc.subjectBetacoronavirusen_US
dc.subjectAntiviral Agentsen_US
dc.subjectChloroquineen_US
dc.subjectSystematic Reviewen_US
dc.subjectRandomized Controlled Trialen_US
dc.titleRepositioned chloroquine and hydroxychloroquine as antiviral prophylaxis for COVID-19: A protocol for rapid systematic review of randomized controlled trialsen_US
eihealth.countryGlobal (WHO/OMS)en_US
eihealth.categoryCandidate therapeutics RDen_US
eihealth.typePublished Articleen_US
eihealth.maincategorySave Lives / Salvar Vidasen_US
dc.relation.ispartofjournalmedRxiven_US


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