dc.contributor.author | Rodrigues, Carina et al. | |
dc.date.accessioned | 2020-06-01T15:07:20Z | |
dc.date.available | 2020-06-01T15:07:20Z | |
dc.date.issued | 2020-05-05 | |
dc.identifier.uri | https://doi.org/10.1101/2020.04.25.20079509 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/1657 | |
dc.description.abstract | Background: The COVID-19 pandemic is an emerging concern regarding the potential adverse effects during pregnancy. This study reviews knowledge on the impact of COVID-19 on pregnancy and describes the outcome of published cases of pregnant women diagnosed with COVID-19. Methods: Searches were conducted in PubMed up to 8 April 2020, using PRISMA standards, to identify original published studies describing pregnant women at any gestational age diagnosed COVID-19. There were no date or language restrictions on the search. All identified studies were included irrespective of assumptions on study quality. Results: We identified 30 original studies reporting 212 cases of pregnant women with COVID-19 (30 discharged while pregnant), 200 from China and 12 from other countries. The 182 published deliveries resulted in one stillbirth and 185 live births. Four women with severe COVID-19 required admission to an intensive care unit but no cases of maternal death were reported. There was one neonatal death. Preterm births occurred in 28.7% of cases, but it is unclear whether this was iatrogenic. All cases with amniotic fluid, placenta, and/or cord blood analyzed for the SARS-CoV-2 virus were negative. Four newborns were positive for SARS-CoV-2 and three newborns had high levels of IgM antibodies. Breast milk samples from 13 mothers and described in seven studies showed no evidence of SARS-CoV-2. Conclusion: The evidence related to the effect of COVID-19 on pregnant women is still limited. Pregnant women and newborns should be considered particularly vulnerable populations regarding COVID-19 prevention and management strategies. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | Systematic Review | en_US |
dc.subject | Breast Feeding | en_US |
dc.subject | SARS-CoV | en_US |
dc.subject | Betacoronavirus | en_US |
dc.title | Pregnancy and breastfeeding during COVID-19 pandemic: A systematic review of published pregnancy cases | en_US |
eihealth.country | Global (WHO/OMS) | en_US |
eihealth.category | Epidemiology and epidemiological studies | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Slow Spread / Reducir la Dispersión | en_US |
dc.relation.ispartofjournal | medRxiv | en_US |