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dc.contributor.authorZhu, Lihua et al.
dc.date.accessioned2020-05-18T16:58:42Z
dc.date.available2020-05-18T16:58:42Z
dc.date.issued2020-05-01
dc.identifier.urihttps://doi.org/10.1016/j.cmet.2020.04.021en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12663/1532
dc.description.abstractType 2 diabetes (T2D) is a major comorbidity of COVID-19. However, the impact of blood glucose (BG) control on the degree of required medical interventions and on mortality in patients with COVID-19 and T2D remains uncertain. Thus, we performed a retrospective, multi-centered study of 7,337 cases of COVID-19 in Hubei Province, China, among which 952 had pre-existing T2D. We found that subjects with T2D required more medical interventions and had a significantly higher mortality (7.8% versus 2.7%; adjusted hazard ratio [HR], 1.49) and multiple organ injury than the non-diabetic individuals. Further, we found that well-controlled BG (glycemic variability within 3.9 to 10.0 mmol/L) was associated with markedly lower mortality compared to individuals with poorly controlled BG (upper limit of glycemic variability exceeding 10.0 mmol/L) (adjusted HR, 0.14) during hospitalization. These findings provide clinical evidence correlating improved glycemic control with better outcomes in patients with COVID-19 and pre-existing T2D.en_US
dc.languageEnglishen_US
dc.subjectCOVID-19en_US
dc.subjectCoronavirusen_US
dc.subjectInfectious Diseasesen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectBlood Glucoseen_US
dc.subjectMortalityen_US
dc.subjectSARS-CoV-2en_US
dc.titleAssociation of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetesen_US
eihealth.countryOthersen_US
eihealth.categoryEpidemiology and epidemiological studiesen_US
eihealth.typePublished Articleen_US
eihealth.maincategorySave Lives / Salvar Vidasen_US
dc.relation.ispartofjournalCell Metabolismen_US


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