Mostrar registro simples

dc.contributor.authorPellanda, Lucia C et al.
dc.date.accessioned2020-05-18T13:10:48Z
dc.date.available2020-05-18T13:10:48Z
dc.date.issued2020-05-10
dc.identifier.urihttps://doi.org/10.1101/2020.05.06.20093476en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12663/1517
dc.description.abstractBackground: While the recommended laboratory diagnosis of COVID-19 is a molecular based assay, population-based studies to determine the prevalence of COVID-19 usually use serological assays. Objective: To evaluate the sensitivity and specificity of a rapid diagnostic test for COVID-19 compared to quantitative reverse transcription polymerase chain reaction (qRT-PCR). Methods: We evaluated the sensitivity using a panel of finger prick blood samples from participants >18 years of age that had been tested for COVID-19 by qRT-PCR. For assessing specificity, we used serum samples from the 1982 Pelotas (Brazil) Birth Cohort participants collected in 2012 with no exposure to SARS-CoV-2. Results: The sensitivity of the test was 77.1% (95% CI 66.6 - 85.6), based upon 83 subjects who had tested positive for qRT-PCR at least 10 days before the rapid diagnostic test (RDT). Based upon 100 sera samples, specificity was 98.0% (95% CI 92.9 - 99.8). There was substantial agreement (Kappa score 0.76) between the qRT-PCR results and the RDT. Interpretation. The validation results are well in line with previous assessments of the test, and confirm that it is sufficiently precise for epidemiological studies aimed at monitoring levels and trends of the COVID-19 pandemic.en_US
dc.languageEnglishen_US
dc.subjectCOVID-19en_US
dc.subjectCoronavirusen_US
dc.subjectInfectious Diseasesen_US
dc.subjectSARS-CoVen_US
dc.subjectDrug Therapyen_US
dc.subjectSerologic Testsen_US
dc.subjectPolymerase Chain Reactionen_US
dc.subjectReal-Time Polymerase Chain Reactionen_US
dc.titleSensitivity and specificity of a rapid test for assessment of exposure to SARS-CoV-2 in a community-based setting in Brazilen_US
eihealth.countryBrasilen_US
eihealth.categoryVirus: natural history, transmission and diagnosticsen_US
eihealth.typePublished Articleen_US
eihealth.maincategorySlow Spread / Reducir la Dispersiónen_US
dc.relation.ispartofjournalmedRxiven_US


Arquivos deste item

ArquivosTamanhoFormatoVisualização

Não existem arquivos associados a este item.

Este item aparece na(s) seguinte(s) coleção(s)

Mostrar registro simples