dc.contributor.author | Freedberg, Daniel E. et al. | |
dc.date.accessioned | 2020-05-13T18:40:36Z | |
dc.date.available | 2020-05-13T18:40:36Z | |
dc.date.issued | 2020-05-08 | |
dc.identifier.uri | https://doi.org/10.1101/2020.05.01.20086694 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/1473 | |
dc.description.abstract | Background: The SARS-CoV-2 pandemic has resulted in enormous morbidity and mortality worldwide, yet no medications to date are proven to improve clinical outcomes in hospitalized COVID-19 patients. Famotidine is commonly used for gastric acid suppression but also has recently gained attention as an antiviral that may inhibit SARS-CoV-2 replication. Objective: To determine whether famotidine use is associated with improved clinical outcomes in patients with COVID-19 initially hospitalized to a non-intensive care setting. Design: Retrospective cohort study. Setting: Inpatients at a single academic medical center. Participants: Consecutive hospitalized patients with COVID-19 infection from February 25 to April 13, 2020. Measurements: Famotidine use (exposure); intubation or death (primary outcome) Results: 1,620 hospitalized patients with COVID-19 were analyzed including 84 (5.1%) who received famotidine within 24 hours of hospital admission. There were no differences between famotidine users and non-users in age, body mass index, or comorbidities including diabetes or hypertension. 340 (21%) patients met the study composite outcome of death or intubation. Use of famotidine was associated with reduced risk for death or intubation (adjusted hazard ratio (aHR) 0.40, 95% CI 0.20-0.81) and also with reduced risk for death alone (aHR 0.29, 95% CI 0.11-0.78). Proton pump inhibitors, which also suppress gastric acid, were not associated with reduced risk for death or intubation. In patients without COVID-19 hospitalized during the same time period, no association was observed between use of famotidine and death or intubation. Limitations: Retrospective analysis; non-randomized exposure. Conclusion: Famotidine use is associated with reduced risk of intubation or death in hospitalized COVID-19 patients. Randomized controlled trials are warranted to determine whether famotidine therapy improves outcomes in hospitalized COVID-19 patients. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Cohort Studies | en_US |
dc.subject | Famotidine | en_US |
dc.subject | Treatment Outcome | en_US |
dc.subject | Retrospective Studies | en_US |
dc.subject | Randomized Controlled Trial | en_US |
dc.subject | SARS-CoV | en_US |
dc.title | Famotidine Use is Associated with Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Retrospective Cohort Study | en_US |
eihealth.country | Global (WHO/OMS) | en_US |
eihealth.category | Candidate therapeutics RD | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | medRxiv | en_US |