dc.contributor.author | Gao Sr, Ya et al. | |
dc.date.accessioned | 2020-05-13T17:38:11Z | |
dc.date.available | 2020-05-13T17:38:11Z | |
dc.date.issued | 2020-05-06 | |
dc.identifier.uri | https://doi.org/10.1101/2020.05.01.20087031 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/1469 | |
dc.description.abstract | Background: Cancer patients are considered a highly vulnerable population in the COVID-19 epidemic, but the relationship between cancer and the severity and mortality of patients with COVID-19 remains unclear. This study aimed to explore the prevalence of cancer in patients with COVID-19 and to examine whether cancer patients with COVID-19 may be at an increased risk of severe illness and mortality. Methods: A comprehensive electronic search in seven databases was performed, to identified studies reporting the prevalence of cancer in COVID-19 patients, or providing data of cancer between patients with severe or non-severe illness or between non-survivors and survivors. Meta-analyses were performed to estimate the pooled prevalence and odds risk (OR) using the inverse variance method with the random-effects model. Results: Thirty-four studies with 8080 patients were included. The pooled prevalence of cancer in patients with COVID-19 was 2.0% (95% CI: 2.0% to 3.0%). The prevalence in Italy (5.0%), France (6.0%), and Korea (4.0%) were higher than that in China (2.0%). Cancer was associated with a 2.84-fold significantly increased risk of severe illness (OR = 2.84, 95%CI: 1.75 to 4.62, P < 0.001) and a 2.60-fold increased risk of death (OR = 2.60, 95%CI: 1.28 to 5.26, P = 0.008) in patients with COVID-19. Sensitivity analyses showed that the results were stable after excluding studies with a sample size of less than 100. Conclusions: Cancer patients have an increased risk of COVID-19 and cancer was associated with a significantly increased risk of severity and mortality of patients with COVID-19. | en_US |
dc.language | English | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Neoplasms | en_US |
dc.subject | Meta-Analysis | en_US |
dc.subject | Systematic Review | en_US |
dc.subject | Mortality | en_US |
dc.title | Cancer is associated with the severity and mortality of patients with COVID-19: a systematic review and meta-analysis | en_US |
eihealth.country | Global (WHO/OMS) | en_US |
eihealth.category | Clinical characterization and management | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | medRxiv | en_US |