dc.contributor.author | Sciascia, Savino et al. | |
dc.date.accessioned | 2020-05-08T22:10:20Z | |
dc.date.available | 2020-05-08T22:10:20Z | |
dc.date.issued | 2020-05-01 | |
dc.identifier.uri | https://www.clinexprheumatol.org/abstract.asp?a=15723 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/1420 | |
dc.description.abstract | Objectives: No agent has yet been proven to be effective for the treatment of patients with severe COVID-19.
Methods: We conducted a pilot prospective open, single-arm multicentre study on off-label use of tocilizumab (TCZ) involving 63 hospitalised adult patients (56 males, age 62.6±12.5) with severe COVID-19. Clinical and laboratory parameters were prospectively collected at baseline, day 1, 2, 7 and 14. No moderate-to severe adverse events attributable to TCZ were recorded.
Results: We observed a significant improvement in the levels of ferritin, C-reactive protein, D-dimer. The ratio of the partial pressure of oxygen (Pa02) to the fraction of inspired oxygen (Fi02) improved (mean±SD Pa02/Fi02 at admission: 152±53; at day 7: 283.73 ± 115.9, at day 14: 302.2 ± 126, p<0.05). The overall mortality was 11%; D-dimer level at baseline, but not IL-6 levels were predictors of mortality. TCZ administration within 6 days from admission in the hospital was associated with an increased likelihood of survival (HR 2.2 95%CI 1.3-6.7, p<0.05).
Conclusions: In hospitalised adult patients with severe COVID-19, TCZ could be a safe option. An improvement in respiratory and laboratory parameters was observed. Future controlled trials in patients with severe illness are urgently needed to confirm the definite benefit with IL-6 target therapy. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Pneumonia | en_US |
dc.title | Pilot Prospective Open, Single-Arm Multicentre Study on Off-Label Use of Tocilizumab in Patients With Severe COVID-19 | en_US |
eihealth.country | Others | en_US |
eihealth.category | Candidate therapeutics RD | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | Clinical and Experimental Rheumatology | en_US |