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dc.contributor.authorLei, Fang et al.
dc.date.accessioned2020-05-08T21:55:02Z
dc.date.available2020-05-08T21:55:02Z
dc.date.issued2020-05-02
dc.identifier.urihttps://doi.org/10.1002/hep.31301en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12663/1419
dc.description.abstractCoronavirus disease 2019 (COVID‐19) is a new infectious disease. To reveal the hepatic injury related to this disease and its clinical significance, we conducted a multicenter retrospective cohort study that included 5,771 adult patients with COVID‐19 pneumonia in Hubei Province. We reported the distributional and temporal patterns of liver injury indicators in these patients and determined their associated factors and death risk. Longitudinal liver function tests were retrospectively analyzed and correlated with the risk factors and death. Liver injury dynamic patterns differed in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TBIL). AST elevated first, followed by ALT, in severe patients. ALP modestly increased during hospitalization and largely remained in the normal range. The fluctuation in TBIL levels was mild in the non‐severe and the severe group. AST abnormality was associated with the highest mortality risk compared to other indicators of liver injury during hospitalization. Common factors associated with elevated liver injury indicators were lymphocyte count decrease, neutrophil count increase, and male gender. Conclusion: The dynamic patterns of liver injury indicators and their potential risk factors may provide an important explanation for the COVID‐19‐associated liver injury. Because elevated liver injury indicators, particularly AST, are strongly associated with the mortality risk, our study indicates that these parameters should be monitored during hospitalization.en_US
dc.languageEnglishen_US
dc.subjectCoronavirusen_US
dc.subjectCOVID-19en_US
dc.subjectInfectious Diseasesen_US
dc.subjectTomography, Emission-Computeden_US
dc.subjectSARS-CoV-2en_US
dc.subjectBilirubinen_US
dc.titleLongitudinal association between markers of liver injury and mortality in COVID‐19 in Chinaen_US
eihealth.countryOthersen_US
eihealth.categoryClinical characterization and managementen_US
eihealth.typeOther publicationsen_US
eihealth.maincategorySave Lives / Salvar Vidasen_US
dc.relation.ispartofjournalHepatologyen_US


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